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- W2101473824 endingPage "323" @default.
- W2101473824 startingPage "315" @default.
- W2101473824 abstract "Transcription factors critical for normal hematopoietic stem cell functions are frequently mutated in acute leukemia leading to an aberrant re-programming of normal hematopoietic progenitor/stem cells into leukemic stem cells. Among them, re-arrangements of the mixed lineage leukemia gene (MLL), including chimeric fusion, partial tandem duplication (PTD), amplification and internal exonic deletion, represent one of the most common recurring oncogenic events and associate with very poor prognosis in human leukemias. Extensive research on wild type MLL and MLL-fusions has significant advanced our knowledge about their functions in normal and malignant hematopoiesis, which also provides a framework for the underlying pathogenic role of MLL re-arrangements in human leukemias. In contrast, research progress on MLL-PTD, MLL amplification and internal exonic deletion remains stagnant, in particular for the last two abnormalities where mouse model is not yet available. In this article, we will review the key features of both wild-type and re-arranged MLL proteins with particular focuses on MLL-PTD and MLL amplification for their roles in normal and malignant hematopoiesis." @default.
- W2101473824 created "2016-06-24" @default.
- W2101473824 creator A5050223014 @default.
- W2101473824 creator A5050440806 @default.
- W2101473824 date "2013-03-01" @default.
- W2101473824 modified "2023-09-24" @default.
- W2101473824 title "Mixed lineage leukemia protein in normal and leukemic stem cells" @default.
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- W2101473824 doi "https://doi.org/10.1177/1535370213480717" @default.
- W2101473824 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23598978" @default.
- W2101473824 hasPublicationYear "2013" @default.
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