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- W2101473940 abstract "Objectives Antifertility effects of Dalbergia sissoo in male mice were investigated.Methods Adult Parkes strain male mice were orally administered aqueous leaf extract of Dalbergia sissoo (50 and 100 mg/kg body weight/day) or distilled water or no treatment (controls) for 35 days (n = 5/group). Motility, viability and number of spermatozoa in the cauda epididymidis; testis histology; serum level of testosterone; and toxicological parameters were evaluated. To assess reversibility, more mice were treated with 100 mg/kg body weight of Dalbergia sissoo or distilled water (n = 5/group) for 35 days and sacrificed 56 days later. Fertility was also assessed separately.Results Histologically, testes of Dalbergia-treated mice showed dissimilar degenerative changes in the seminiferous tubules. Significant reductions were noted (i) in epididymal sperm motility, viability and number, and (ii) in serum level of testosterone in Dalbergia-treated mice compared to controls. However, serum levels of alanine aminotransferase, aspartate aminotransferase and creatinine, and haematological parameters were not affected. Also libido of Dalbergia–treated males showed no change, but their fertility was markedly suppressed. By 56 days of treatment withdrawal, alterations induced in the above parameters returned to control levels.Conclusions Dalbergia sissoo treatment caused reversible suppression of spermatogenesis and fertility in P mice, without eliciting detectable toxic effects.Chinese Abstract摘要 目的 研究印度黄檀对雄性小鼠的抗生育作用。方法 选取成年帕克斯小鼠，每组5只小鼠，研究组小鼠采用印度黄檀叶液态提取物口服给药方法（50和100毫克/公斤体重/天），另外两组分别采用蒸馏水喂养（50和100毫克/公斤体重/天）或者无任何处理。评价指标包括：采集小鼠附睾尾部精子，观察指标包括精子运动、活力和数量；睾丸组织学检测；血清睾酮水平；毒理学参数。为评估可逆性，额外每组5只小鼠，分别给予印度黄檀叶提取物100mg/公斤体重或者蒸馏水100mg/公斤体重，共35天，56天后处死两组小鼠。生育也被单独评估。结果 组织学方面，黄檀组小鼠睾丸生精小管表现出不同程度的退行性变化。研究组和对照组比较，小鼠附睾精子的运动、活力和数量差异有显著性，血清睾酮水平差异有显著性。但是，血清丙氨酸氨基转移酶，天门冬氨酸氨基转移酶和肌酐，以及血液学参数均无显著性差异。黄檀组小鼠性欲未受影响，但是他们的生育能力明显下降。56天后去除各种诱导因素的小鼠的各项生育指标又恢复至对照组水平。结论 印度黄檀可导致帕克斯小鼠精子发生和生育力的可逆性下降。没有产生可检测到毒性作用。" @default.
- W2101473940 created "2016-06-24" @default.
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- W2101473940 date "2014-08-12" @default.
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- W2101473940 title "Effect of aqueous leaf extract of<i>Dalbergia sissoo</i>Roxb. on spermatogenesis and fertility in male mice" @default.
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- W2101473940 doi "https://doi.org/10.3109/13625187.2014.945165" @default.
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