FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2101476502> ?p ?o ?g. }

• W2101476502 endingPage "H583" @default.
• W2101476502 startingPage "H576" @default.
• W2101476502 abstract "Previous studies showed increased phospholemman (PLM) mRNA after myocardial infarction (MI) in rats (Sehl PD, Tai JTN, Hillan KJ, Brown LA, Goddard A, Yang R, Jin H, and Lowe DG. Circulation 101: 1990-1999, 2000). We tested the hypothesis that, in normal adult rat cardiac myocytes, PLM overexpression alters contractile function and cytosolic Ca(2+) concentration ([Ca(2+)](i)) homeostasis in a manner similar to that observed in post-MI myocytes. Compared with myocytes infected by control adenovirus expressing green fluorescent protein (GFP) alone, Western blots indicated a 41% increase in PLM expression after 72 h (P < 0.001) but no changes in Na(+)/Ca(2+) exchanger, SERCA2, and calsequestrin levels in myocytes infected by adenovirus expressing GFP and PLM. At 5 mM extracellular [Ca(2+)] ([Ca(2+)](o)), maximal contraction amplitudes in PLM-overexpressed myocytes were 24% (P < 0.005) and [Ca(2+)](i) transient amplitudes were 18% (P < 0.05) lower than control myocytes. At 0.6 mM [Ca(2+)](o), however, contraction and [Ca(2+)](i) transient amplitudes were significantly (P < 0.05) higher in PLM-overexpressed than control myocytes (18% and 42%, respectively); at 1.8 mM [Ca(2+)](o), the differences in contraction and [Ca(2+)](i) transient amplitudes were narrowed. This pattern of contractile and [Ca(2+)](i) transient abnormalities in PLM-overexpressed myocytes mimics that observed in post-MI rat myocytes. We suggest that PLM overexpression observed in post-MI myocytes may partly account for contractile abnormalities by perturbing Ca(2+) fluxes during excitation-contraction." @default.
• W2101476502 created "2016-06-24" @default.
• W2101476502 creator A5000828286 @default.
• W2101476502 creator A5048141186 @default.
• W2101476502 creator A5048518146 @default.
• W2101476502 creator A5085167135 @default.
• W2101476502 creator A5088772174 @default.
• W2101476502 creator A5044581187 @default.
• W2101476502 date "2002-08-01" @default.
• W2101476502 modified "2023-10-18" @default.
• W2101476502 title "Overexpression of phospholemman alters contractility and [Ca²⁺]_itransients in adult rat myocytes" @default.
• W2101476502 cites W1493985344 @default.
• W2101476502 cites W1518588038 @default.
• W2101476502 cites W1606565754 @default.
• W2101476502 cites W1900822909 @default.
• W2101476502 cites W1973332969 @default.
• W2101476502 cites W1977752983 @default.
• W2101476502 cites W2000702715 @default.
• W2101476502 cites W2012635677 @default.
• W2101476502 cites W2021775223 @default.
• W2101476502 cites W2061272525 @default.
• W2101476502 cites W2068748822 @default.
• W2101476502 cites W2112192126 @default.
• W2101476502 cites W2136879982 @default.
• W2101476502 cites W2136960074 @default.
• W2101476502 cites W2138161492 @default.
• W2101476502 cites W2151318859 @default.
• W2101476502 cites W2162542232 @default.
• W2101476502 cites W2164996871 @default.
• W2101476502 cites W2166442426 @default.
• W2101476502 cites W2166716835 @default.
• W2101476502 cites W2184229176 @default.
• W2101476502 cites W2197264447 @default.
• W2101476502 cites W2211275235 @default.
• W2101476502 cites W2230175451 @default.
• W2101476502 cites W2249641836 @default.
• W2101476502 cites W2286019065 @default.
• W2101476502 cites W2306055648 @default.
• W2101476502 cites W2341687344 @default.
• W2101476502 cites W2401085244 @default.
• W2101476502 cites W2419639524 @default.
• W2101476502 cites W36429972 @default.
• W2101476502 cites W4242846507 @default.
• W2101476502 cites W4253422011 @default.
• W2101476502 doi "https://doi.org/10.1152/ajpheart.00197.2002" @default.
• W2101476502 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12124204" @default.
• W2101476502 hasPublicationYear "2002" @default.
• W2101476502 type Work @default.
• W2101476502 sameAs 2101476502 @default.
• W2101476502 citedByCount "38" @default.
• W2101476502 countsByYear W21014765022012 @default.
• W2101476502 countsByYear W21014765022013 @default.
• W2101476502 countsByYear W21014765022014 @default.
• W2101476502 countsByYear W21014765022015 @default.
• W2101476502 countsByYear W21014765022017 @default.
• W2101476502 countsByYear W21014765022019 @default.
• W2101476502 crossrefType "journal-article" @default.
• W2101476502 hasAuthorship W2101476502A5000828286 @default.
• W2101476502 hasAuthorship W2101476502A5044581187 @default.
• W2101476502 hasAuthorship W2101476502A5048141186 @default.
• W2101476502 hasAuthorship W2101476502A5048518146 @default.
• W2101476502 hasAuthorship W2101476502A5085167135 @default.
• W2101476502 hasAuthorship W2101476502A5088772174 @default.
• W2101476502 hasConcept C126322002 @default.
• W2101476502 hasConcept C134018914 @default.
• W2101476502 hasConcept C163415756 @default.
• W2101476502 hasConcept C181199279 @default.
• W2101476502 hasConcept C185592680 @default.
• W2101476502 hasConcept C207200792 @default.
• W2101476502 hasConcept C28406088 @default.
• W2101476502 hasConcept C39133596 @default.
• W2101476502 hasConcept C55493867 @default.
• W2101476502 hasConcept C71924100 @default.
• W2101476502 hasConcept C86803240 @default.
• W2101476502 hasConcept C95444343 @default.
• W2101476502 hasConcept C98539663 @default.
• W2101476502 hasConceptScore W2101476502C126322002 @default.
• W2101476502 hasConceptScore W2101476502C134018914 @default.
• W2101476502 hasConceptScore W2101476502C163415756 @default.
• W2101476502 hasConceptScore W2101476502C181199279 @default.
• W2101476502 hasConceptScore W2101476502C185592680 @default.
• W2101476502 hasConceptScore W2101476502C207200792 @default.
• W2101476502 hasConceptScore W2101476502C28406088 @default.
• W2101476502 hasConceptScore W2101476502C39133596 @default.
• W2101476502 hasConceptScore W2101476502C55493867 @default.
• W2101476502 hasConceptScore W2101476502C71924100 @default.
• W2101476502 hasConceptScore W2101476502C86803240 @default.
• W2101476502 hasConceptScore W2101476502C95444343 @default.
• W2101476502 hasConceptScore W2101476502C98539663 @default.
• W2101476502 hasIssue "2" @default.
• W2101476502 hasLocation W21014765021 @default.
• W2101476502 hasLocation W21014765022 @default.
• W2101476502 hasOpenAccess W2101476502 @default.
• W2101476502 hasPrimaryLocation W21014765021 @default.
• W2101476502 hasRelatedWork W1822099413 @default.
• W2101476502 hasRelatedWork W1977123617 @default.
• W2101476502 hasRelatedWork W2026559022 @default.
• W2101476502 hasRelatedWork W2043471606 @default.

• next