FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2101476601> ?p ?o ?g. }

• W2101476601 endingPage "496" @default.
• W2101476601 startingPage "490" @default.
• W2101476601 abstract "In previous studies, we have observed that endothelin participates in the progression of renal vascular and glomerular fibrosis during hypertension by activating collagen I gene synthesis. The present study investigated whether administration of endothelin receptor antagonists leads to the regression of renal sclerotic lesions. Experiments were performed in transgenic mice harboring the luciferase gene under the control of the collagen I-alpha2 chain promoter. Hypertension was induced by long-term inhibition of nitric oxide synthesis by N(G)-nitro-L-arginine methyl ester (L-NAME); systolic pressure gradually increased, reaching a plateau of 165 mm Hg after 10 weeks of hypertensive treatment. At the same time, collagen I gene expression was increased 2- and 5-fold compared with control animals in afferent arterioles and glomeruli, respectively (P<0.01). This increase was accompanied by the appearance of sclerotic lesions within the renal vasculature. When renal vascular lesions had been established (20 weeks of L-NAME), animals were divided into 2 subgroups: the one continued to receive L-NAME, whereas in the other, bosentan, a dual endothelin antagonist, was coadministered with L-NAME for an additional period of 10 weeks. Bosentan coadministration did not alter the increased systolic pressure at 30 weeks; in contrast, collagen I gene activity returned almost to control levels in renal vessels and glomeruli. In this subgroup of animals, renal vascular lesions (collagen and/or extracellular matrix deposition) and mortality rates were substantially reduced compared with untreated mice. These data indicate that endothelin participates in the mechanism(s) of renal vascular fibrosis by activating collagen I gene. Treatment with an endothelin antagonist normalizes expression of collagen I gene and leads to the regression of renal vascular fibrosis and to the improvement of survival, thus providing a complementary curative approach against renal fibrotic complications associated with hypertension." @default.
• W2101476601 created "2016-06-24" @default.
• W2101476601 creator A5006316949 @default.
• W2101476601 creator A5018600927 @default.
• W2101476601 creator A5055492584 @default.
• W2101476601 creator A5076876029 @default.
• W2101476601 date "2001-02-01" @default.
• W2101476601 modified "2023-10-16" @default.
• W2101476601 title "Regression of Renal Vascular Fibrosis by Endothelin Receptor Antagonism" @default.
• W2101476601 cites W1971585190 @default.
• W2101476601 cites W1994887713 @default.
• W2101476601 cites W2012497346 @default.
• W2101476601 cites W2041075406 @default.
• W2101476601 cites W2056966654 @default.
• W2101476601 cites W2057866040 @default.
• W2101476601 cites W2066895998 @default.
• W2101476601 cites W2076584321 @default.
• W2101476601 cites W2088790253 @default.
• W2101476601 cites W2097571046 @default.
• W2101476601 cites W2109591901 @default.
• W2101476601 cites W2116865084 @default.
• W2101476601 cites W2119718874 @default.
• W2101476601 cites W2162858709 @default.
• W2101476601 cites W2266058855 @default.
• W2101476601 cites W2267563665 @default.
• W2101476601 cites W2329868635 @default.
• W2101476601 doi "https://doi.org/10.1161/01.hyp.37.2.490" @default.
• W2101476601 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11230324" @default.
• W2101476601 hasPublicationYear "2001" @default.
• W2101476601 type Work @default.
• W2101476601 sameAs 2101476601 @default.
• W2101476601 citedByCount "90" @default.
• W2101476601 countsByYear W21014766012012 @default.
• W2101476601 countsByYear W21014766012013 @default.
• W2101476601 countsByYear W21014766012014 @default.
• W2101476601 countsByYear W21014766012015 @default.
• W2101476601 countsByYear W21014766012016 @default.
• W2101476601 countsByYear W21014766012017 @default.
• W2101476601 countsByYear W21014766012018 @default.
• W2101476601 countsByYear W21014766012019 @default.
• W2101476601 countsByYear W21014766012020 @default.
• W2101476601 countsByYear W21014766012021 @default.
• W2101476601 countsByYear W21014766012022 @default.
• W2101476601 countsByYear W21014766012023 @default.
• W2101476601 crossrefType "journal-article" @default.
• W2101476601 hasAuthorship W2101476601A5006316949 @default.
• W2101476601 hasAuthorship W2101476601A5018600927 @default.
• W2101476601 hasAuthorship W2101476601A5055492584 @default.
• W2101476601 hasAuthorship W2101476601A5076876029 @default.
• W2101476601 hasBestOaLocation W21014766011 @default.
• W2101476601 hasConcept C126322002 @default.
• W2101476601 hasConcept C134018914 @default.
• W2101476601 hasConcept C142724271 @default.
• W2101476601 hasConcept C144980905 @default.
• W2101476601 hasConcept C149601957 @default.
• W2101476601 hasConcept C170493617 @default.
• W2101476601 hasConcept C2776345702 @default.
• W2101476601 hasConcept C2779869378 @default.
• W2101476601 hasConcept C2780091579 @default.
• W2101476601 hasConcept C2780559512 @default.
• W2101476601 hasConcept C2780636983 @default.
• W2101476601 hasConcept C2781109936 @default.
• W2101476601 hasConcept C2908929049 @default.
• W2101476601 hasConcept C71924100 @default.
• W2101476601 hasConcept C84393581 @default.
• W2101476601 hasConceptScore W2101476601C126322002 @default.
• W2101476601 hasConceptScore W2101476601C134018914 @default.
• W2101476601 hasConceptScore W2101476601C142724271 @default.
• W2101476601 hasConceptScore W2101476601C144980905 @default.
• W2101476601 hasConceptScore W2101476601C149601957 @default.
• W2101476601 hasConceptScore W2101476601C170493617 @default.
• W2101476601 hasConceptScore W2101476601C2776345702 @default.
• W2101476601 hasConceptScore W2101476601C2779869378 @default.
• W2101476601 hasConceptScore W2101476601C2780091579 @default.
• W2101476601 hasConceptScore W2101476601C2780559512 @default.
• W2101476601 hasConceptScore W2101476601C2780636983 @default.
• W2101476601 hasConceptScore W2101476601C2781109936 @default.
• W2101476601 hasConceptScore W2101476601C2908929049 @default.
• W2101476601 hasConceptScore W2101476601C71924100 @default.
• W2101476601 hasConceptScore W2101476601C84393581 @default.
• W2101476601 hasIssue "2" @default.
• W2101476601 hasLocation W21014766011 @default.
• W2101476601 hasLocation W21014766012 @default.
• W2101476601 hasOpenAccess W2101476601 @default.
• W2101476601 hasPrimaryLocation W21014766011 @default.
• W2101476601 hasRelatedWork W1979626596 @default.
• W2101476601 hasRelatedWork W1983371938 @default.
• W2101476601 hasRelatedWork W2012497346 @default.
• W2101476601 hasRelatedWork W2059812109 @default.
• W2101476601 hasRelatedWork W2101476601 @default.
• W2101476601 hasRelatedWork W2160355439 @default.
• W2101476601 hasRelatedWork W2163671238 @default.
• W2101476601 hasRelatedWork W2369362743 @default.
• W2101476601 hasRelatedWork W2381977691 @default.
• W2101476601 hasRelatedWork W4248973018 @default.
• W2101476601 hasVolume "37" @default.
• W2101476601 isParatext "false" @default.
• W2101476601 isRetracted "false" @default.

• next