FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2101476813> ?p ?o ?g. }

• W2101476813 endingPage "AB96" @default.
• W2101476813 startingPage "AB96" @default.
• W2101476813 abstract "Objectives: Photodynamic therapy (PDT) for unresectable cholangiocarcinoma reportedly results in reduction of cholestasis, improved quality of life, and improved survival. We report the effect of ERCP with PDT on survival in unresectable cholangiocarcinoma, using a cohort receiving only ERCP with biliary stenting for statistical comparison. Methods: Between December 2001 and November 2006, 48 patients aged 66 ± 13.4 years (range: 26-94) were palliated for unresectable cholangiocarcinoma. Nineteen were treated with PDT and stents (mean PDT session 1.6, range: 1-3); 29 patients treated with biliary stents alone served as a control group. Multivariate analysis was performed using MELD score, age, treatment by chemotherapy or radiation, number of ERCP and PDT to detect predictors of survival. Results: Patients in the stent group received a median number of 2 ERCPs (range: 1-13); in the PDT group, 3.0 (range: 1-8). Mean drop in serum bilirubin after 3 months was similar between both groups. Kaplan-Meier analysis demonstrated improved survival in the PDT group compared to the stent only group (16.2 months vs 7.4 months - p < 0.004). Mortality in the PDT group at 3, 6 and 12 months was 0%, 16% and 56% respectively. The corresponding mortality in the stent group was 28%, 52% and 82% respectively. The difference between the two groups was significant at 3 months (p < 0.01), 6 months (p < 0.01), but not at 12 months (p = 0.08). Only the number of ERCP and exposure to PDT were significant on multivariate analysis (Table 1). Adverse events specific to PDT included three patients with skin phototoxicity requiring topical therapy only. Conclusion: PDT is minimally invasive and effective in restoring biliary drainage in patients with unresectable cholangiocarcinoma. Survival appears prolonged when compared to stenting alone. It remains to be proven if this effect is attributable to PDT or multiple ERCP sessions. A prospective randomized multicenter study is required to define these issues. Tabled 1Factors predictive of survival Variable P value Odds ratio 95% CI Age 0.9001 0.998 0.969-1.028 Meld score 0.6947 1.016 0.938-1.102 PDT 0.0062 0.270 0.105-0.689 Chemotherapy 0.9285 1.074 0.228-5.059 Radiation 0.1850 0.308 0.054-1.757 ERCP sessions 0.0002 0.650 0.517-0.818 Open table in a new tab" @default.
• W2101476813 created "2016-06-24" @default.
• W2101476813 creator A5020089431 @default.
• W2101476813 creator A5021101281 @default.
• W2101476813 creator A5023478509 @default.
• W2101476813 creator A5027588353 @default.
• W2101476813 creator A5030512802 @default.
• W2101476813 creator A5038517805 @default.
• W2101476813 creator A5039061943 @default.
• W2101476813 creator A5042683693 @default.
• W2101476813 creator A5047241507 @default.
• W2101476813 creator A5062167342 @default.
• W2101476813 creator A5066095034 @default.
• W2101476813 creator A5070164458 @default.
• W2101476813 creator A5088852895 @default.
• W2101476813 date "2007-04-01" @default.
• W2101476813 modified "2023-10-14" @default.
• W2101476813 title "Unresectable Cholangiocarcinoma: Does Photodynamic Therapy (PDT) with Stenting Increase Survival When Compared to Stenting Alone?" @default.
• W2101476813 doi "https://doi.org/10.1016/j.gie.2007.03.106" @default.
• W2101476813 hasPublicationYear "2007" @default.
• W2101476813 type Work @default.
• W2101476813 sameAs 2101476813 @default.
• W2101476813 citedByCount "0" @default.
• W2101476813 crossrefType "journal-article" @default.
• W2101476813 hasAuthorship W2101476813A5020089431 @default.
• W2101476813 hasAuthorship W2101476813A5021101281 @default.
• W2101476813 hasAuthorship W2101476813A5023478509 @default.
• W2101476813 hasAuthorship W2101476813A5027588353 @default.
• W2101476813 hasAuthorship W2101476813A5030512802 @default.
• W2101476813 hasAuthorship W2101476813A5038517805 @default.
• W2101476813 hasAuthorship W2101476813A5039061943 @default.
• W2101476813 hasAuthorship W2101476813A5042683693 @default.
• W2101476813 hasAuthorship W2101476813A5047241507 @default.
• W2101476813 hasAuthorship W2101476813A5062167342 @default.
• W2101476813 hasAuthorship W2101476813A5066095034 @default.
• W2101476813 hasAuthorship W2101476813A5070164458 @default.
• W2101476813 hasAuthorship W2101476813A5088852895 @default.
• W2101476813 hasConcept C10515644 @default.
• W2101476813 hasConcept C126322002 @default.
• W2101476813 hasConcept C141071460 @default.
• W2101476813 hasConcept C178790620 @default.
• W2101476813 hasConcept C185592680 @default.
• W2101476813 hasConcept C2778583881 @default.
• W2101476813 hasConcept C2778593092 @default.
• W2101476813 hasConcept C2781323092 @default.
• W2101476813 hasConcept C38180746 @default.
• W2101476813 hasConcept C71924100 @default.
• W2101476813 hasConcept C72563966 @default.
• W2101476813 hasConcept C90924648 @default.
• W2101476813 hasConceptScore W2101476813C10515644 @default.
• W2101476813 hasConceptScore W2101476813C126322002 @default.
• W2101476813 hasConceptScore W2101476813C141071460 @default.
• W2101476813 hasConceptScore W2101476813C178790620 @default.
• W2101476813 hasConceptScore W2101476813C185592680 @default.
• W2101476813 hasConceptScore W2101476813C2778583881 @default.
• W2101476813 hasConceptScore W2101476813C2778593092 @default.
• W2101476813 hasConceptScore W2101476813C2781323092 @default.
• W2101476813 hasConceptScore W2101476813C38180746 @default.
• W2101476813 hasConceptScore W2101476813C71924100 @default.
• W2101476813 hasConceptScore W2101476813C72563966 @default.
• W2101476813 hasConceptScore W2101476813C90924648 @default.
• W2101476813 hasIssue "5" @default.
• W2101476813 hasLocation W21014768131 @default.
• W2101476813 hasOpenAccess W2101476813 @default.
• W2101476813 hasPrimaryLocation W21014768131 @default.
• W2101476813 hasRelatedWork W2047967234 @default.
• W2101476813 hasRelatedWork W2064665390 @default.
• W2101476813 hasRelatedWork W2159986890 @default.
• W2101476813 hasRelatedWork W2251065806 @default.
• W2101476813 hasRelatedWork W2291821906 @default.
• W2101476813 hasRelatedWork W2402795263 @default.
• W2101476813 hasRelatedWork W2983005728 @default.
• W2101476813 hasRelatedWork W3143885487 @default.
• W2101476813 hasRelatedWork W3213718466 @default.
• W2101476813 hasRelatedWork W4281974528 @default.
• W2101476813 hasVolume "65" @default.
• W2101476813 isParatext "false" @default.
• W2101476813 isRetracted "false" @default.
• W2101476813 magId "2101476813" @default.
• W2101476813 workType "article" @default.