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- W2101477036 abstract "Dichlorvos, a synthetic organophosphate toxin, is used as pesticides. These toxins can be used as pesticides in farming and medicine for the devastation and/or elimination of ectoparasites of animals. Reports have shown that Dichlorvos generate seizure effects in various animals. Potassium channel opener is extensively used for medication of cardiovascular and other diseases. Studies have shown that potassium channel opener has anticonvulsant effects in different animal models. The goal of this study was to evaluate the effect of dizoxide on Dichlorvos-induced seizures in mice. In this research, the animals received different doses of Diazoxide (1, 2.5, 5, 10, and 20 mg/kg b.wt.) intraperitoneally 30 min before intraperitoneal injection of Dichlorvos (50 mg/kg b.w.t). After Dichlorvos injection, latency of clones, severity of seizure, and finally death as the fate were investigated. Results showed that Diazoxide dose-dependently decreased the severity of Dichlorvos-induced seizures, so that Diazoxide at a dose of 5 mg (the lowest, <svg style=vertical-align:-0.1638pt;width:58.712502px; id=M1 height=11.375 version=1.1 viewBox=0 0 58.712502 11.375 width=58.712502 xmlns:xlink=http://www.w3.org/1999/xlink xmlns=http://www.w3.org/2000/svg> <g transform=matrix(.017,-0,0,-.017,.062,11.112)><path id=x1D443 d=M619 482q0 -69 -40.5 -119t-96 -72.5t-118.5 -26.5h-44l-70 20l-31 -151q-14 -67 0.5 -83t89.5 -22l-5 -28h-287l8 28q65 7 81.5 22t29.5 83l79 398q12 56 0.5 70.5t-78.5 20.5l7 28h255q108 0 164 -43t56 -125zM524 478q0 141 -146 141q-25 0 -47 -8q-16 -6 -20.5 -13.5
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l-26 -65h-233z /></g> </svg>) and 20 mg/kg b.wt. (the highest, <svg style=vertical-align:-0.1638pt;width:66.875px; id=M2 height=11.375 version=1.1 viewBox=0 0 66.875 11.375 width=66.875 xmlns:xlink=http://www.w3.org/1999/xlink xmlns=http://www.w3.org/2000/svg> <g transform=matrix(.017,-0,0,-.017,.062,11.112)><use xlink:href=#x1D443/></g><g transform=matrix(.017,-0,0,-.017,15.582,11.112)><use xlink:href=#x3C/></g><g transform=matrix(.017,-0,0,-.017,30.286,11.112)><use xlink:href=#x30/></g><g transform=matrix(.017,-0,0,-.017,38.446,11.112)><use xlink:href=#x2E/></g><g transform=matrix(.017,-0,0,-.017,42.321,11.112)><use xlink:href=#x30/></g><g transform=matrix(.017,-0,0,-.017,50.481,11.112)><use xlink:href=#x30/></g><g transform=matrix(.017,-0,0,-.017,58.64,11.112)><path id=x31 d=M384 0h-275v27q67 5 81.5 18.5t14.5 68.5v385q0 38 -7.5 47.5t-40.5 10.5l-48 2v24q85 15 178 52v-521q0 -55 14.5 -68.5t82.5 -18.5v-27z /></g> </svg>) has anticonvulsant effects. Thus, our data suggest that diazoxide as ATP-sensitive potassium channels opener has anticonvulsant activity against dichlorvas-induced seizure." @default.
- W2101477036 created "2016-06-24" @default.
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- W2101477036 date "2013-01-01" @default.
- W2101477036 modified "2023-10-18" @default.
- W2101477036 title "Anticonvulsant Effect of Diazoxide against Dichlorvos-Induced Seizures in Mice" @default.
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- W2101477036 doi "https://doi.org/10.1155/2013/697305" @default.
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