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- W2101477316 abstract "Conclusion: Carotid plaque ulceration and thrombus are more prevalent in symptomatic patients. Summary: This was a microscopic analysis of carotid plaques surgically removed from patients enrolled in the North American Symptomatic Carotid Endarterectomy Trial (NASCET), and in the Asymptomatic Carotid Atherosclerosis Study (ACAS). Microscopic plaque morphology was compared in patients with and without stroke symptoms ipsilateral and contralateral to the plaque. The presence of calcification, thrombus, and ulceration were used to characterize the plaques. There were a total of 241 subjects from whom plaques were obtained with 128 subjects having no history of stroke symptoms, 80 subjects with symptoms ipsilateral to the plaque and 33 with symptoms contralateral to the plaque. Of the subjects, 170 had been enrolled in ACAS and 71 in NASCET. Ulceration of the plaque was more common when the plaque was removed from a symptomatic patient than when the plaque was obtained from an asymptomatic patient (36% versus 14%; P < 0.001). The frequency of ulceration was similar in plaques associated with ipsilateral (34%) and contralateral symptoms (42%). Thrombus was more common in plaques removed from patients with both ipsilateral symptoms and ulceration. Calcification was not associated with stroke symptoms. Comment: This is another indirect attempt trying to determine which plaques in asymptomatic patients may have a greater propensity to produce stroke. The authors conclusions are not new, not unexpected, and add very little to what is already known or suspected. There continues to be great interest in characterizing surgically removed plaques. What is needed is a preoperative marker of plaque virulence that is sufficiently sensitive and powerful to improve selection of patients with asymptomatic carotid stenosis for a prophylactic carotid intervention." @default.
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- W2101477316 date "2006-04-01" @default.
- W2101477316 modified "2023-09-26" @default.
- W2101477316 title "Carotid plaque pathology: Thrombosis, ulceration, and stroke pathogenesis" @default.
- W2101477316 doi "https://doi.org/10.1016/j.jvs.2006.03.014" @default.
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