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- W2101478520 abstract "Uncoupling protein (UCP), the mitochondrial protein specific to brown adipose tissue, is activated transcriptionally in response to cold and adrenergic agents. We studied the role of triiodothyronine (T 3 ) on the adrenergic stimulation of UCP mRNA expression by use of primary cultures of rat brown adipocytes. Basal UCP mRNA levels are undetectable. Norepinephrine (NE) increases UCP mRNA during differentiation, not during proliferation. In hypothyroid conditions, UCP mRNA response to NE is almost absent. The presence of T 3 (0.2–20 nM) greatly increases the adrenergic response (30-fold). The sensitivity of UCP mRNA responses to NE is potentiated ∼100-fold by the presence of T 3 . The effect is proportional to the dose and time of preexposure to T 3 . The increases obtained with NE and T 3 are prevented by actinomycin and cycloheximide. T 3 greatly stabilizes UCP mRNA transcripts. The effects of thyroxine and retinoic acid are weaker than those of T 3 . In conclusion, in cultured rat brown adipocytes, T 3 is required and both synergizes with NE to increase UCP mRNA and stabilizes its mRNA transcripts." @default.
- W2101478520 created "2016-06-24" @default.
- W2101478520 creator A5029303884 @default.
- W2101478520 creator A5030192169 @default.
- W2101478520 date "2000-05-01" @default.
- W2101478520 modified "2023-10-03" @default.
- W2101478520 title "Triiodothyronine amplifies the adrenergic stimulation of uncoupling protein expression in rat brown adipocytes" @default.
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- W2101478520 doi "https://doi.org/10.1152/ajpendo.2000.278.5.e769" @default.
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