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• W2101478742 abstract "No AccessJournal of UrologyINVESTIGATIVE UROLOGY1 Nov 2003Angiotensin II Dependent Testicular Fibrosis and Effects on Spermatogenesis After Vasectomy in the Rat KOJI SHIRAISHI, KEN-ICHI YOSHIDA, TATSUYA FUJIMIYA, and KATSUSUKE NAITO KOJI SHIRAISHIKOJI SHIRAISHI More articles by this author , KEN-ICHI YOSHIDAKEN-ICHI YOSHIDA More articles by this author , TATSUYA FUJIMIYATATSUYA FUJIMIYA More articles by this author , and KATSUSUKE NAITOKATSUSUKE NAITO More articles by this author View All Author Informationhttps://doi.org/10.1097/01.ju.0000080299.29929.f9AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Vasectomy induces testicular interstitial fibrosis in time dependent fashion and inhibits spermatogenesis. We investigated the contribution of angiotensin II (Ang II) to the development of interstitial fibrosis after vasectomy. Materials and Methods: Bilateral vasectomy was performed in 8-week-old Wistar rats and the testes were harvested 1 to 24 weeks after vasectomy. Interstitial fibrosis was evaluated by Masson’s trichrome staining. Western blotting and immunohistochemistry were done to examine the expressions of heat shock protein 47 (HSP47), HNE (4-hydroxy-2,3-nonenal) and transforming growth factor-β1 (TGF-β1). The antioxidative agent N-acetylcysteine (NAC), the Ang II type 1 receptor antagonist losartan or the Ang converting enzyme inhibitor enalapril was given orally for 24 weeks to vasectomized rats. Spermatogenesis was evaluated by testicular weight and the percent of haploid cells was analyzed by flow cytometry. Results: Vasectomy significantly increased interstitial fibrosis (more than 8 weeks) and induced the expression of HSP47, HNE modified protein and TGF-β1. TGF-β1 and HSP47 immunoreactivity was localized to Leydig cells and fibroblasts. NAC or losartan but not enalapril inhibited the expression of these molecules induced by vasectomy. Increased interstitial fibrosis and impaired spermatogenesis were partially abrogated by NAC or losartan administration. Conclusions: There is Ang II type 1 receptor dependent fibrosis after vasectomy. Oxidative condition is considered to trigger and promote these fibrogenic processes. Ang II contributes to the regulation of intratesticular autocrine or paracrine functions after vasectomy. References 1 : Quantitative pathologic changes in the human testis after vasectomy. A controlled study. N Engl J Med1985; 313: 1252. Google Scholar 2 : Influence of interstitial fibrosis on spermatogenesis after vasectomy and vasovasostomy. Contraception2002; 65: 245. Google Scholar 3 : Pituitary-dependent renin-like immunoreactivity in rat testis. Endocrinology1983; 112: 1318. 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Google Scholar 10 : Stimulation of lipid peroxidation or 4-hydroxynonenal treatment increases procollagen alpha 1(I) gene expression in human lever fat-storing cells. Biochem Biophys Res Commun1993; 194: 1044. Google Scholar 11 : A major collagen-binding protein of chick embryo fibroblasts is a novel heat shock protein. J Cell Biol1986; 103: 223. Google Scholar 12 : Interactions of transforming growth factor-beta and angiotensin II in renal fibrosis. Hypertension1998; 31: 181. Google Scholar 13 : Activation of mitogen activated protein kinases and apoptosis of germ cells after vasectomy in the rat. J Urol2002; 168: 1273. Link, Google Scholar 14 : Differential gene expression and regulation of type-1 angiotensin II receptor subtypes in the rat. Biochem Biophys Res Commun1992; 188: 446. Google Scholar 15 : Significance of human testicular mast cells and their subtypes in male infertility. Hum Reprod2000; 15: 1543. Google Scholar 16 : Identification of a highly specific chymase as the major angiotensin II-forming enzyme in the human heart. J Biol Chem1990; 265: 22348. Google Scholar 17 : Angiotensin receptors. J Hypertension1996; 14: 95. Google Scholar 18 : Mast cell tryptase stimulates the synthesis of type I collagen in human lung fibroblasts. J Clin Invest1997; 99: 1313. Google Scholar 19 : Transcriptional activation of the mouse HSP47 gene in mouse osteoblast MC3T3–E1 cells by TGF-beta 1. Biochem Biophys Res Commun1998; 244: 68. Google Scholar From the Department of Urology and Forensic Medicine, Yamaguchi University School of Medicine and the Department of Forensic Medicine, Graduate School of Medicine, University of Tokyo© 2003 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byShiraishi K and Naito K (2018) Effects of 4-Hydroxy-2-Nonenal, a Marker of Oxidative Stress, on Spermatogenesis and Expression of p53 Protein in Male InfertilityJournal of Urology, VOL. 178, NO. 3, (1012-1017), Online publication date: 1-Sep-2007. Volume 170Issue 5November 2003Page: 2104-2108 Advertisement Copyright & Permissions© 2003 by American Urological Association, Inc.Keywordsspermatogenesistestisrats, WistarfibrosisLeydig cellsMetricsAuthor Information KOJI SHIRAISHI More articles by this author KEN-ICHI YOSHIDA More articles by this author TATSUYA FUJIMIYA More articles by this author KATSUSUKE NAITO More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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