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- W2101486545 abstract "Adult mesenchymal stem cells (MSCs) obtainable from autologous bone marrow aspirates have generated tre- mendous interest in the medical and scientific communities in the last two decades and are currently being investigated by a of interested physicians for use in point-of-care stem cell therapies due to their great potential to differentiate into multi- ple cell lineages such as bone, cartilage, muscle, tendon, and nerve. However, as these stem cells are found in very low numbers in adult tissue, centrifugal concentration or expansion through in vitro culturing has been pursued to obtain higher numbers of efficacious regenerative therapeutic applications. More recently, some physicians and scientists have chosen to explore use for direct injection of un-fractionated, native whole bone marrow aspirate as a strategy in regenera- tive treatment regimes. This review examines the potential merits and disadvantages of using either concentrated and culture expanded MSCs versus native whole bone marrow aspirate as key proliferant in direct regenerative injection ther- apy (RIT). Results from a number of published investigations have clearly shown high potential of various deleterious ef- fects on manipulating MSCs obtained from native bone marrow aspirate either by centrifugal forces or expansion through in vitro culturing; moreover, currently used centrifugal concentration techniques do not significantly concentrate MSCs from bone marrow aspirate, thus, defeating the purpose of this manipulative step. On the other hand, preliminary results and observations of using un-fractionated whole bone marrow injection for treatment of various musculoskeletal joint dis- eases (for example, osteoarthritic joints) suggest that the procedure is safe and potentially efficacious, with no known deleterious effects as yet reported." @default.
- W2101486545 created "2016-06-24" @default.
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- W2101486545 date "2013-01-01" @default.
- W2101486545 modified "2023-09-27" @default.
- W2101486545 title "Rationale for Using Direct Bone Marrow Aspirate as a Proliferant for Regenerative Injection Therapy (Prolotherapy)" @default.
- W2101486545 cites W1556372290 @default.
- W2101486545 cites W155929268 @default.
- W2101486545 cites W1580455904 @default.
- W2101486545 cites W1800391173 @default.
- W2101486545 cites W1964768285 @default.
- W2101486545 cites W1964772955 @default.
- W2101486545 cites W1965708095 @default.
- W2101486545 cites W1965953554 @default.
- W2101486545 cites W1966852966 @default.
- W2101486545 cites W1966939529 @default.
- W2101486545 cites W1968181528 @default.
- W2101486545 cites W1970527851 @default.
- W2101486545 cites W1980164146 @default.
- W2101486545 cites W1982323513 @default.
- W2101486545 cites W1983971888 @default.
- W2101486545 cites W1987393210 @default.
- W2101486545 cites W1988680604 @default.
- W2101486545 cites W1991677352 @default.
- W2101486545 cites W1993640536 @default.
- W2101486545 cites W1993959445 @default.
- W2101486545 cites W2009521351 @default.
- W2101486545 cites W2015856405 @default.
- W2101486545 cites W2022311887 @default.
- W2101486545 cites W2031366673 @default.
- W2101486545 cites W2034094910 @default.
- W2101486545 cites W2040324631 @default.
- W2101486545 cites W2040404307 @default.
- W2101486545 cites W2040959498 @default.
- W2101486545 cites W2048224359 @default.
- W2101486545 cites W2051169916 @default.
- W2101486545 cites W2052465339 @default.
- W2101486545 cites W2056963249 @default.
- W2101486545 cites W2061453726 @default.
- W2101486545 cites W2067750770 @default.
- W2101486545 cites W2068111593 @default.
- W2101486545 cites W2070356929 @default.
- W2101486545 cites W2070435400 @default.
- W2101486545 cites W2077435353 @default.
- W2101486545 cites W2082586271 @default.
- W2101486545 cites W2086794837 @default.
- W2101486545 cites W2087164901 @default.
- W2101486545 cites W2098459519 @default.
- W2101486545 cites W2106316818 @default.
- W2101486545 cites W2107264623 @default.
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- W2101486545 cites W2114066412 @default.
- W2101486545 cites W2116500923 @default.
- W2101486545 cites W2118602810 @default.
- W2101486545 cites W2124315774 @default.
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- W2101486545 cites W2134515785 @default.
- W2101486545 cites W2135698835 @default.
- W2101486545 cites W2142400618 @default.
- W2101486545 cites W2144268541 @default.
- W2101486545 cites W2150600914 @default.
- W2101486545 cites W2150661797 @default.
- W2101486545 cites W2151455227 @default.
- W2101486545 cites W2153405392 @default.
- W2101486545 cites W2159999899 @default.
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- W2101486545 cites W2614290614 @default.
- W2101486545 cites W1484815935 @default.
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- W2101486545 doi "https://doi.org/10.2174/1876893801304010007" @default.
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