FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2101557613> ?p ?o ?g. }

• W2101557613 endingPage "6252" @default.
• W2101557613 startingPage "6245" @default.
• W2101557613 abstract "A peptide corresponding to the epidermal growth factor homology domain of β-heregulin stimulated autophosphorylation of the heregulin receptors erbB2 and erbB3 in Schwann cells and activation of the mitogen-activated protein (MAP) kinases ERK1 and ERK2. Heregulin-dependent activation of PAK65, a component of the stress-activated signaling pathway, ribosomal S6 kinase, and a cyclic AMP (cAMP) response element binding protein (CREB) kinase, identified as p95RSK2, was also observed. Receptor phosphorylation and activation of these kinases in response to heregulin occurred in the absence of forskolin stimulation and were not augmented in cells treated with forskolin, a direct activator of adenylyl cyclase. Schwann cell proliferation in response to heregulin was observed only when the cells were also exposed to an agent that elevates cAMP levels. In the absence of heregulin, elevation of cAMP levels failed to stimulate Schwann cell proliferation. Forskolin significantly enhanced heregulin-stimulated expression of cyclin D and phosphorylation of the retinoblastoma gene product. In cells treated with both heregulin and forskolin there was a sustained accumulation of phospho-CREB, which was not observed in cells treated with either agent alone. Heregulin and forskolin synergistically activated transcription of a cyclin D promoter construct. These results demonstrate that heregulin-stimulated activation of MAP kinase is not sufficient to induce maximal Schwann cell proliferation. Expression of critical cell cycle regulatory proteins and cell division require activation of both heregulin and cAMP-dependent processes." @default.
• W2101557613 created "2016-06-24" @default.
• W2101557613 creator A5014308331 @default.
• W2101557613 creator A5026689644 @default.
• W2101557613 creator A5032415588 @default.
• W2101557613 creator A5058929353 @default.
• W2101557613 creator A5062328911 @default.
• W2101557613 creator A5074651593 @default.
• W2101557613 date "1998-11-01" @default.
• W2101557613 modified "2023-09-26" @default.
• W2101557613 title "Synergistic Regulation of Schwann Cell Proliferation by Heregulin and Forskolin" @default.
• W2101557613 cites W1555692789 @default.
• W2101557613 cites W1586779185 @default.
• W2101557613 cites W1603981767 @default.
• W2101557613 cites W1777065333 @default.
• W2101557613 cites W1899513052 @default.
• W2101557613 cites W1967251640 @default.
• W2101557613 cites W1973188134 @default.
• W2101557613 cites W1977333251 @default.
• W2101557613 cites W1977677084 @default.
• W2101557613 cites W1986388513 @default.
• W2101557613 cites W1992821829 @default.
• W2101557613 cites W1997914540 @default.
• W2101557613 cites W1999330214 @default.
• W2101557613 cites W2001441118 @default.
• W2101557613 cites W2004813091 @default.
• W2101557613 cites W2012828388 @default.
• W2101557613 cites W2014111401 @default.
• W2101557613 cites W2016405898 @default.
• W2101557613 cites W2022713347 @default.
• W2101557613 cites W2027310689 @default.
• W2101557613 cites W2029080338 @default.
• W2101557613 cites W2040397739 @default.
• W2101557613 cites W2042295629 @default.
• W2101557613 cites W2047909489 @default.
• W2101557613 cites W2053423807 @default.
• W2101557613 cites W2064129448 @default.
• W2101557613 cites W2081524299 @default.
• W2101557613 cites W2115113861 @default.
• W2101557613 cites W2115940913 @default.
• W2101557613 cites W2132468193 @default.
• W2101557613 cites W2146538952 @default.
• W2101557613 cites W2146943926 @default.
• W2101557613 cites W2164180561 @default.
• W2101557613 cites W2313211164 @default.
• W2101557613 cites W2344695725 @default.
• W2101557613 doi "https://doi.org/10.1128/mcb.18.11.6245" @default.
• W2101557613 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/109211" @default.
• W2101557613 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9774641" @default.
• W2101557613 hasPublicationYear "1998" @default.
• W2101557613 type Work @default.
• W2101557613 sameAs 2101557613 @default.
• W2101557613 citedByCount "99" @default.
• W2101557613 countsByYear W21015576132013 @default.
• W2101557613 countsByYear W21015576132014 @default.
• W2101557613 countsByYear W21015576132015 @default.
• W2101557613 countsByYear W21015576132016 @default.
• W2101557613 countsByYear W21015576132017 @default.
• W2101557613 countsByYear W21015576132018 @default.
• W2101557613 countsByYear W21015576132019 @default.
• W2101557613 countsByYear W21015576132020 @default.
• W2101557613 countsByYear W21015576132021 @default.
• W2101557613 countsByYear W21015576132022 @default.
• W2101557613 countsByYear W21015576132023 @default.
• W2101557613 crossrefType "journal-article" @default.
• W2101557613 hasAuthorship W2101557613A5014308331 @default.
• W2101557613 hasAuthorship W2101557613A5026689644 @default.
• W2101557613 hasAuthorship W2101557613A5032415588 @default.
• W2101557613 hasAuthorship W2101557613A5058929353 @default.
• W2101557613 hasAuthorship W2101557613A5062328911 @default.
• W2101557613 hasAuthorship W2101557613A5074651593 @default.
• W2101557613 hasBestOaLocation W21015576131 @default.
• W2101557613 hasConcept C101544691 @default.
• W2101557613 hasConcept C115456853 @default.
• W2101557613 hasConcept C134018914 @default.
• W2101557613 hasConcept C153911025 @default.
• W2101557613 hasConcept C185323287 @default.
• W2101557613 hasConcept C24998067 @default.
• W2101557613 hasConcept C2779276759 @default.
• W2101557613 hasConcept C62478195 @default.
• W2101557613 hasConcept C86803240 @default.
• W2101557613 hasConcept C95444343 @default.
• W2101557613 hasConceptScore W2101557613C101544691 @default.
• W2101557613 hasConceptScore W2101557613C115456853 @default.
• W2101557613 hasConceptScore W2101557613C134018914 @default.
• W2101557613 hasConceptScore W2101557613C153911025 @default.
• W2101557613 hasConceptScore W2101557613C185323287 @default.
• W2101557613 hasConceptScore W2101557613C24998067 @default.
• W2101557613 hasConceptScore W2101557613C2779276759 @default.
• W2101557613 hasConceptScore W2101557613C62478195 @default.
• W2101557613 hasConceptScore W2101557613C86803240 @default.
• W2101557613 hasConceptScore W2101557613C95444343 @default.
• W2101557613 hasIssue "11" @default.
• W2101557613 hasLocation W21015576131 @default.
• W2101557613 hasLocation W21015576132 @default.
• W2101557613 hasLocation W21015576133 @default.
• W2101557613 hasOpenAccess W2101557613 @default.
• W2101557613 hasPrimaryLocation W21015576131 @default.

• next