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- W2101567874 abstract "The centromere is a complex chromosomal locus where the kinetochore is formed and microtubules attach during cell division. Centromere identity involves both genomic and sequence-independent (epigenetic) mechanisms. Current models for how centromeres are formed and, conversely, turned off have emerged from studies of unusual or engineered chromosomes, such as neocentromeres, artificial chromosomes, and dicentric chromosomes. Recent studies have highlighted the importance of unique chromatin marked by the histone H3 variant CENP-A, classical chromatin (heterochromatin and euchromatin), and transcription during centromere activation and inactivation. These advances have deepened our view of what defines a centromere and how it behaves in various genomic and chromatin contexts." @default.
- W2101567874 created "2016-06-24" @default.
- W2101567874 creator A5059283391 @default.
- W2101567874 creator A5072468999 @default.
- W2101567874 date "2010-12-01" @default.
- W2101567874 modified "2023-10-16" @default.
- W2101567874 title "Epigenomics of centromere assembly and function" @default.
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- W2101567874 doi "https://doi.org/10.1016/j.ceb.2010.07.002" @default.
- W2101567874 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20675111" @default.
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