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• W2101604013 abstract "The discovery that even small changes in extracellular acidity can alter the excitability of neuronal networks via activation of acid-sensing ion channels (ASICs) could have therapeutic application in a host of neurological and psychiatric illnesses. Recent evidence suggests that activation of ASIC1a, a subtype of ASICs that is widely distributed in the brain, is necessary for the expression of fear and anxiety. Antagonists of ASIC1a, therefore, have been proposed as a potential treatment for anxiety. The basolateral amygdala (BLA) is central to fear generation, and anxiety disorders are characterized by BLA hyperexcitability. To better understand the role of ASIC1a in anxiety, we attempted to provide a direct assessment of whether ASIC1a activation increases BLA excitability. In rat BLA slices, activation of ASIC1a by low pH or ammonium elicited inward currents in both interneurons and principal neurons, and increased spontaneous IPSCs recorded from principal cells significantly more than spontaneous EPSCs. Epileptiform activity induced by high potassium and low magnesium was suppressed by ammonium. Antagonism of ASIC1a decreased spontaneous IPSCs more than EPSCs, and increased the excitability of the BLA network, as reflected by the pronounced increase of evoked field potentials, suggesting that ASIC1a channels are active in the basal state. In vivo activation or blockade of ASIC1a in the BLA suppressed or increased, respectively, anxiety-like behavior. Thus, in the rat BLA, ASIC1a has an inhibitory and anxiolytic function. The discovery of positive ASIC1a modulators may hold promise for the treatment of anxiety disorders." @default.
• W2101604013 created "2016-06-24" @default.
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• W2101604013 date "2014-02-26" @default.
• W2101604013 modified "2023-10-16" @default.
• W2101604013 title "ASIC1a Activation Enhances Inhibition in the Basolateral Amygdala and Reduces Anxiety" @default.
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• W2101604013 cites W1862230085 @default.
• W2101604013 cites W1965134629 @default.
• W2101604013 cites W1967502463 @default.
• W2101604013 cites W1972476800 @default.
• W2101604013 cites W1972585935 @default.
• W2101604013 cites W1974642350 @default.
• W2101604013 cites W1980440878 @default.
• W2101604013 cites W1982469667 @default.
• W2101604013 cites W1985214064 @default.
• W2101604013 cites W1985440826 @default.
• W2101604013 cites W1986895579 @default.
• W2101604013 cites W1989289789 @default.
• W2101604013 cites W1990955686 @default.
• W2101604013 cites W1992767102 @default.
• W2101604013 cites W1992979412 @default.
• W2101604013 cites W1996447493 @default.
• W2101604013 cites W1999531604 @default.
• W2101604013 cites W2009882594 @default.
• W2101604013 cites W2011201599 @default.
• W2101604013 cites W2014671181 @default.
• W2101604013 cites W2016166286 @default.
• W2101604013 cites W2016772559 @default.
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• W2101604013 cites W2022211793 @default.
• W2101604013 cites W2023589715 @default.
• W2101604013 cites W2031554042 @default.
• W2101604013 cites W2037546692 @default.
• W2101604013 cites W2039183819 @default.
• W2101604013 cites W2039548603 @default.
• W2101604013 cites W2052987076 @default.
• W2101604013 cites W2053752711 @default.
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• W2101604013 cites W2070671106 @default.
• W2101604013 cites W2070961029 @default.
• W2101604013 cites W2071364551 @default.
• W2101604013 cites W2075312117 @default.
• W2101604013 cites W2078549137 @default.
• W2101604013 cites W2079102265 @default.
• W2101604013 cites W2079435575 @default.
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• W2101604013 cites W2086387632 @default.
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• W2101604013 doi "https://doi.org/10.1523/jneurosci.4009-13.2014" @default.
• W2101604013 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3935079" @default.
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