Matches in SemOpenAlex for { <https://semopenalex.org/work/W2101605125> ?p ?o ?g. }
- W2101605125 endingPage "11" @default.
- W2101605125 startingPage "1" @default.
- W2101605125 abstract "KIOM-MA was recently reported as a novel herbal medicine effective for atopic dermatitis and asthma. In this study, we have demonstrated the inhibitory effect of KIOM-MA on proinflammatory mediator produced in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. KIOM-MA significantly inhibited the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) as well as nitric oxide (NO) and prostaglandin E(2) (PGE(2)). Consistent with the inhibitory effect on PGE(2), KIOM-MA suppresses the LPS-induced migration of macrophages and gelatinase activity and the expression of matrix metalloprotease-9 (MMP-9) in a dose-dependent manner. Additionally, KIOM-MA showed a strong suppressive effect on the inflammatory cytokines production such as tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6). We also found that KIOM-MA inhibits the activation of nuclear factor-κB (NF-κB) and represses the activity of extracellular signal-regulated kinase (ERK), p38, and c-Jun NH(2)-terminal kinase (JNK) mitogen-activated protein kinases (MAPKs). Taken together, we elucidated the mechanism of anti-inflammatory effect of KIOM-MA using RAW 264.7 cells stimulated by LPS." @default.
- W2101605125 created "2016-06-24" @default.
- W2101605125 creator A5000763100 @default.
- W2101605125 creator A5003882041 @default.
- W2101605125 creator A5008031606 @default.
- W2101605125 creator A5016137020 @default.
- W2101605125 creator A5018435296 @default.
- W2101605125 creator A5024706853 @default.
- W2101605125 creator A5040824493 @default.
- W2101605125 creator A5064402810 @default.
- W2101605125 creator A5070652882 @default.
- W2101605125 date "2012-01-01" @default.
- W2101605125 modified "2023-09-22" @default.
- W2101605125 title "A Novel Herbal Medicine KIOM-MA Exerts an Anti-Inflammatory Effect in LPS-Stimulated RAW 264.7 Macrophage Cells" @default.
- W2101605125 cites W1509979785 @default.
- W2101605125 cites W1591881963 @default.
- W2101605125 cites W173128540 @default.
- W2101605125 cites W1976326847 @default.
- W2101605125 cites W1984554579 @default.
- W2101605125 cites W1984771171 @default.
- W2101605125 cites W1984993711 @default.
- W2101605125 cites W1985644715 @default.
- W2101605125 cites W1987107938 @default.
- W2101605125 cites W1992896008 @default.
- W2101605125 cites W1993354784 @default.
- W2101605125 cites W1994512268 @default.
- W2101605125 cites W1996024698 @default.
- W2101605125 cites W1999177172 @default.
- W2101605125 cites W2000258847 @default.
- W2101605125 cites W2001751920 @default.
- W2101605125 cites W2013704058 @default.
- W2101605125 cites W2016457314 @default.
- W2101605125 cites W2017306058 @default.
- W2101605125 cites W2020712752 @default.
- W2101605125 cites W2023404740 @default.
- W2101605125 cites W2025023014 @default.
- W2101605125 cites W2038197749 @default.
- W2101605125 cites W2043671043 @default.
- W2101605125 cites W2049625770 @default.
- W2101605125 cites W2051327588 @default.
- W2101605125 cites W2051509131 @default.
- W2101605125 cites W2052908553 @default.
- W2101605125 cites W2061772316 @default.
- W2101605125 cites W2073677430 @default.
- W2101605125 cites W2075211725 @default.
- W2101605125 cites W2079613572 @default.
- W2101605125 cites W2081220230 @default.
- W2101605125 cites W2085738299 @default.
- W2101605125 cites W2089561780 @default.
- W2101605125 cites W2110728146 @default.
- W2101605125 cites W2111122008 @default.
- W2101605125 cites W2114647686 @default.
- W2101605125 cites W2116094765 @default.
- W2101605125 cites W2125515765 @default.
- W2101605125 cites W2129043456 @default.
- W2101605125 cites W2142351770 @default.
- W2101605125 cites W2152571985 @default.
- W2101605125 cites W2331176038 @default.
- W2101605125 cites W2332387324 @default.
- W2101605125 doi "https://doi.org/10.1155/2012/462383" @default.
- W2101605125 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3518860" @default.
- W2101605125 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23243447" @default.
- W2101605125 hasPublicationYear "2012" @default.
- W2101605125 type Work @default.
- W2101605125 sameAs 2101605125 @default.
- W2101605125 citedByCount "14" @default.
- W2101605125 countsByYear W21016051252014 @default.
- W2101605125 countsByYear W21016051252015 @default.
- W2101605125 countsByYear W21016051252016 @default.
- W2101605125 countsByYear W21016051252017 @default.
- W2101605125 countsByYear W21016051252018 @default.
- W2101605125 countsByYear W21016051252021 @default.
- W2101605125 countsByYear W21016051252023 @default.
- W2101605125 crossrefType "journal-article" @default.
- W2101605125 hasAuthorship W2101605125A5000763100 @default.
- W2101605125 hasAuthorship W2101605125A5003882041 @default.
- W2101605125 hasAuthorship W2101605125A5008031606 @default.
- W2101605125 hasAuthorship W2101605125A5016137020 @default.
- W2101605125 hasAuthorship W2101605125A5018435296 @default.
- W2101605125 hasAuthorship W2101605125A5024706853 @default.
- W2101605125 hasAuthorship W2101605125A5040824493 @default.
- W2101605125 hasAuthorship W2101605125A5064402810 @default.
- W2101605125 hasAuthorship W2101605125A5070652882 @default.
- W2101605125 hasBestOaLocation W21016051251 @default.
- W2101605125 hasConcept C134018914 @default.
- W2101605125 hasConcept C164027704 @default.
- W2101605125 hasConcept C17991360 @default.
- W2101605125 hasConcept C184235292 @default.
- W2101605125 hasConcept C185592680 @default.
- W2101605125 hasConcept C203014093 @default.
- W2101605125 hasConcept C2776914184 @default.
- W2101605125 hasConcept C2777622882 @default.
- W2101605125 hasConcept C2778754761 @default.
- W2101605125 hasConcept C51551487 @default.
- W2101605125 hasConcept C519581460 @default.
- W2101605125 hasConcept C55493867 @default.
- W2101605125 hasConcept C57074206 @default.
- W2101605125 hasConcept C71924100 @default.