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• W2101617109 startingPage "747" @default.
• W2101617109 abstract "Hypertension or hypercholesterolemia can induce a proinflammatory and prothrombogenic phenotype in the microcirculation of the brain; however, less is known about how the combination of these risk factors affects the vasculature. We recently reported that a moderate (60%) increase in plasma cholesterol blunts the recruitment of leukocytes and platelets in the cerebral microvessels elicited by hypertension. In this study, we examined whether larger increments in blood cholesterol (4-fold) exerts a similar modulating influence on the vasculature in the presence of hypertension. Apolipoprotein E-knockout mice with deoxycorticosterone acetate salt-induced hypertension were placed on a high-cholesterol diet and exhibited exaggerated leukocyte and platelet adhesion responses in cerebral microvessels. Intermittent feeding (every fourth day) with high-cholesterol diet yielded similar phenotypic changes in the vasculature. Once the mice were placed on high-cholesterol diet, 4 days on normal diet (ND) were needed to revert to a normal vascular phenotype. Angiotensin II type 1 receptors and reactive oxygen species seem to contribute to the vascular responses induced by hypercholesterolemia and hypertension. Our findings indicate that the combination of hypertension and large increases in plasma cholesterol concentration results in a severe, but reversible, inflammatory and thrombogenic phenotype in the cerebral microvasculature." @default.
• W2101617109 created "2016-06-24" @default.
• W2101617109 creator A5073530398 @default.
• W2101617109 creator A5075585663 @default.
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• W2101617109 date "2014-04-01" @default.
• W2101617109 modified "2023-10-03" @default.
• W2101617109 title "Synergistic Effects of High Blood Cholesterol and Hypertension on Leukocyte and Platelet Recruitment in the Cerebral Microcirculation" @default.
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• W2101617109 doi "https://doi.org/10.1161/hypertensionaha.113.02627" @default.
• W2101617109 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3966559" @default.
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