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• W2101640726 abstract "Whole-genome sequence data from samples of natural populations provide fertile grounds for analyses of intraspecific variation and tests of population genetic theory. We show that the urochordate Ciona savignyi , one of the species of ocean-dwelling broadcast spawners commonly known as sea squirts, exhibits the highest rates of single-nucleotide and structural polymorphism ever comprehensively quantified in a multicellular organism. We demonstrate that the cause for the extreme heterozygosity is a large effective population size, and, consistent with prediction by the neutral theory, we find evidence of strong purifying selection. These results constitute in-depth insight into the dynamics of highly polymorphic genomes and provide important empirical support of population genetic theory as it pertains to population size, heterozygosity, and natural selection." @default.
• W2101640726 created "2016-06-24" @default.
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• W2101640726 date "2007-03-27" @default.
• W2101640726 modified "2023-10-16" @default.
• W2101640726 title "Extreme genomic variation in a natural population" @default.
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• W2101640726 doi "https://doi.org/10.1073/pnas.0700890104" @default.
• W2101640726 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1838466" @default.
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