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• W2101651607 abstract "To establish the diurnal stability of edited magnetic resonance spectroscopy measurements of gamma-aminobutyric acid (GABA) in visual and sensorimotor regions of the brain.GABA measurements were made in two regions of the brain (an occipital, visual region and a sensorimotor region centered on the precentral gyrus) using the MEGA-PRESS editing method, scanning eight healthy adults at five timepoints during a single day. GABA concentration was quantified from the ratio of the GABA integral to the unsuppressed water signal.No significant effect of time on GABA concentration was seen (P = 0.35). GABA was shown to be significantly more concentrated in visual regions than in sensorimotor regions (1.10 i.u. and 1.03 i.u., respectively; P = 0.050). Coefficients of variability (CVs) across all subjects of 9.1% and 12% (visual and sensorimotor) were significantly higher than mean within-subjects CVs of 6.5% and 8.8.This study demonstrates the excellent reproducibility of MEGA-PRESS detection of GABA, demonstrating that the method is sufficiently sensitive to detect inter-subject variability, and suggests that (within the sensitivity limits of current measurements) time of day can be ignored in the design of MRS studies of visual and sensorimotor regions." @default.
• W2101651607 created "2016-06-24" @default.
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• W2101651607 date "2009-12-20" @default.
• W2101651607 modified "2023-09-24" @default.
• W2101651607 title "Diurnal stability of γ-aminobutyric acid concentration in visual and sensorimotor cortex" @default.
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• W2101651607 doi "https://doi.org/10.1002/jmri.21996" @default.
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