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- W2101655783 abstract "Using numerical simulations of pairs of long polymeric chains confined in microscopic cylinders, we investigate consequences of double-strand DNA breaks occurring in independent topological domains, such as these constituting bacterial chromosomes. Our simulations show a transition between segregated and mixed state upon linearization of one of the modelled topological domains. Our results explain how chromosomal organization into topological domains can fulfil two opposite conditions: (i) effectively repulse various loops from each other thus promoting chromosome separation and (ii) permit local DNA intermingling when one or more loops are broken and need to be repaired in a process that requires homology search between broken ends and their homologous sequences in closely positioned sister chromatid." @default.
- W2101655783 created "2016-06-24" @default.
- W2101655783 creator A5001116361 @default.
- W2101655783 creator A5057093594 @default.
- W2101655783 date "2013-06-05" @default.
- W2101655783 modified "2023-09-27" @default.
- W2101655783 title "Modelling of crowded polymers elucidate effects of double-strand breaks in topological domains of bacterial chromosomes" @default.
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- W2101655783 doi "https://doi.org/10.1093/nar/gkt480" @default.
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