Matches in SemOpenAlex for { <https://semopenalex.org/work/W2101661569> ?p ?o ?g. }
- W2101661569 endingPage "3668" @default.
- W2101661569 startingPage "3660" @default.
- W2101661569 abstract "Localized controlled release of anti-fibrogenic factors can potentially prevent tissue fibrosis surrounding biomedical prostheses, such as vascular stents and breast implants. We have previously demonstrated that therapeutic intervention with topically applied stratifin in a rabbit ear fibrotic model not only prevents dermal fibrosis but also promotes more normal tissue repair by regulating extracellular matrix deposition. In this work, the anti-fibrogenic effect of a controlled release form of stratifin was investigated in the prevention of fibrosis induced by dermal poly(lactic-co-glycolic acid) (PLGA) microsphere/poly(vinyl alcohol) (PVA) hydrogel implants. Pharmacodynamic effects were evaluated by histopathological examination of subcutaneous tissue surrounding implanted composites. Controlled release of stratifin from PLGA microsphere/PVA hydrogel implants significantly moderated dermal fibrosis and inflammation by reducing collagen deposition (30%), total tissue cellularity (48%) and infiltrated CD3(+) immune cells (81%) in the surrounding tissue compared with the stratifin-free implants. The controlled release of stratifin from implants markedly increased the level of matrix metalloproteinase-1 expression in the surrounding tissue, which resulted in less collagen deposition. These stratifin-eluting PLGA/PVA composites show promise as coatings to decrease the typical fibrosis exhibited around implanted biomedical prostheses, such as breast implants and vascular stents." @default.
- W2101661569 created "2016-06-24" @default.
- W2101661569 creator A5011013562 @default.
- W2101661569 creator A5050966856 @default.
- W2101661569 creator A5056688281 @default.
- W2101661569 creator A5063403933 @default.
- W2101661569 creator A5064579544 @default.
- W2101661569 creator A5069458499 @default.
- W2101661569 date "2012-10-01" @default.
- W2101661569 modified "2023-10-05" @default.
- W2101661569 title "Localized controlled release of stratifin reduces implantation-induced dermal fibrosis" @default.
- W2101661569 cites W1506649322 @default.
- W2101661569 cites W1550767915 @default.
- W2101661569 cites W173680682 @default.
- W2101661569 cites W1849339882 @default.
- W2101661569 cites W1974185118 @default.
- W2101661569 cites W1986901350 @default.
- W2101661569 cites W1987645206 @default.
- W2101661569 cites W1994046518 @default.
- W2101661569 cites W1995779733 @default.
- W2101661569 cites W2000079001 @default.
- W2101661569 cites W2000593519 @default.
- W2101661569 cites W2001832437 @default.
- W2101661569 cites W2001865162 @default.
- W2101661569 cites W2004482027 @default.
- W2101661569 cites W2008539472 @default.
- W2101661569 cites W2008817044 @default.
- W2101661569 cites W2018463296 @default.
- W2101661569 cites W2021092323 @default.
- W2101661569 cites W2036498908 @default.
- W2101661569 cites W2048408942 @default.
- W2101661569 cites W2069003092 @default.
- W2101661569 cites W2069774710 @default.
- W2101661569 cites W2071521950 @default.
- W2101661569 cites W2077123765 @default.
- W2101661569 cites W2081640562 @default.
- W2101661569 cites W2083630382 @default.
- W2101661569 cites W2084759998 @default.
- W2101661569 cites W2085750440 @default.
- W2101661569 cites W2099103113 @default.
- W2101661569 cites W2105852378 @default.
- W2101661569 cites W2120146996 @default.
- W2101661569 cites W2121496050 @default.
- W2101661569 cites W2137519552 @default.
- W2101661569 cites W2156558921 @default.
- W2101661569 cites W2162807663 @default.
- W2101661569 cites W2165806143 @default.
- W2101661569 cites W2166548167 @default.
- W2101661569 cites W4250908540 @default.
- W2101661569 cites W48820593 @default.
- W2101661569 cites W87818324 @default.
- W2101661569 doi "https://doi.org/10.1016/j.actbio.2012.06.025" @default.
- W2101661569 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22743110" @default.
- W2101661569 hasPublicationYear "2012" @default.
- W2101661569 type Work @default.
- W2101661569 sameAs 2101661569 @default.
- W2101661569 citedByCount "10" @default.
- W2101661569 countsByYear W21016615692014 @default.
- W2101661569 countsByYear W21016615692015 @default.
- W2101661569 countsByYear W21016615692016 @default.
- W2101661569 countsByYear W21016615692017 @default.
- W2101661569 countsByYear W21016615692021 @default.
- W2101661569 crossrefType "journal-article" @default.
- W2101661569 hasAuthorship W2101661569A5011013562 @default.
- W2101661569 hasAuthorship W2101661569A5050966856 @default.
- W2101661569 hasAuthorship W2101661569A5056688281 @default.
- W2101661569 hasAuthorship W2101661569A5063403933 @default.
- W2101661569 hasAuthorship W2101661569A5064579544 @default.
- W2101661569 hasAuthorship W2101661569A5069458499 @default.
- W2101661569 hasConcept C108657112 @default.
- W2101661569 hasConcept C126322002 @default.
- W2101661569 hasConcept C136229726 @default.
- W2101661569 hasConcept C136948725 @default.
- W2101661569 hasConcept C141071460 @default.
- W2101661569 hasConcept C142724271 @default.
- W2101661569 hasConcept C155672457 @default.
- W2101661569 hasConcept C163588942 @default.
- W2101661569 hasConcept C171250308 @default.
- W2101661569 hasConcept C185592680 @default.
- W2101661569 hasConcept C189165786 @default.
- W2101661569 hasConcept C190672674 @default.
- W2101661569 hasConcept C192562407 @default.
- W2101661569 hasConcept C2776914184 @default.
- W2101661569 hasConcept C2780165375 @default.
- W2101661569 hasConcept C2780559512 @default.
- W2101661569 hasConcept C2781411149 @default.
- W2101661569 hasConcept C49892992 @default.
- W2101661569 hasConcept C55493867 @default.
- W2101661569 hasConcept C71924100 @default.
- W2101661569 hasConcept C98274493 @default.
- W2101661569 hasConceptScore W2101661569C108657112 @default.
- W2101661569 hasConceptScore W2101661569C126322002 @default.
- W2101661569 hasConceptScore W2101661569C136229726 @default.
- W2101661569 hasConceptScore W2101661569C136948725 @default.
- W2101661569 hasConceptScore W2101661569C141071460 @default.
- W2101661569 hasConceptScore W2101661569C142724271 @default.
- W2101661569 hasConceptScore W2101661569C155672457 @default.
- W2101661569 hasConceptScore W2101661569C163588942 @default.