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- W2101663310 abstract "Summary 1.A method for the study of biliary motility in resting man was described. It employed a cholecystographic agent labeled with tracer amounts of a γ-emitting radioisotope and appropriate apparatus for measurement of radioactivity in the gall bladder region. 2.With physiological stimulation, radio-activity diminished irregularly for a variable time and became steady. The period of decrement was not exponential, but an exponential function could be fitted to it approximately to derive a measurement of over-all emptying rate at the half time of emptying. The amounts of radioactivity before and after emptying provided a measure of over-all emptying efficiency as the per cent of emptying. 3.With control of collimation and positioning, the over-all emptying rate and efficiency were reproducible in individual subjects. Evidence was obtained that radiation from isotope in bloodstream, liver, or intestine did not affect results significantly. 4.Analysis of the period of radioactive decrement uncovered numerous changes in its rate. Generally, these components of the process of biliary evacuation began inefficiently and became effective after a mean interval of 21 min, often with a single productive phase which accomplished a major portion of the entire evacuation. 5.It was postulated that the steps in biliary emptying were the resultant of the moment-to-moment interplay between gall bladder contraction and resistance in the biliary sphincteric mechanism. 6.Physiological stimulation with fatty meals and continuous intravenous infusions of cholecystokinin gave similar results, although differences in the components of the emptying process with the latter delayed the onset of efficient evacuation. In contrast to both methods of stimulation, rapid intravenous injection of cholecystokinin induced brief and incomplete biliary evacuation." @default.
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- W2101663310 date "1966-04-01" @default.
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- W2101663310 title "Quantitative analysis of human biliary evacuation with a radioisotopic technique" @default.
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- W2101663310 doi "https://doi.org/10.1016/s0016-5085(66)80029-x" @default.
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