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- W2101665157 endingPage "3130" @default.
- W2101665157 startingPage "3117" @default.
- W2101665157 abstract "ABSTRACT Two-component systems (TCS) are principal mechanisms by which bacteria adapt to their surroundings. Borrelia burgdorferi encodes only two TCS. One is comprised of a histidine kinase, Hk2, and the response regulator Rrp2. While the contribution of Hk2 remains unclear, Rrp2 is part of a regulatory pathway involving the spirochete's alternate sigma factors, RpoN and RpoS. Genes within the Rrp2/RpoN/RpoS regulon function to promote tick transmission and early infection. The other TCS consists of a hybrid histidine kinase, Hk1, and the response regulator Rrp1. Hk1 is composed of two periplasmic sensor domains (D1 and D2), followed by conserved cytoplasmic histidine kinase core, REC, and Hpt domains. In addition to its REC domain, Rrp1 contains a GGDEF motif characteristic of diguanylate cyclases. To investigate the role of Hk1 during the enzootic cycle, we inactivated this gene in two virulent backgrounds. Extensive characterization of the resulting mutants revealed a dramatic phenotype whereby Hk1-deficient spirochetes are virulent in mice and able to migrate out of the bite site during feeding but are killed within the midgut following acquisition. We hypothesize that the phosphorelay between Hk1 and Rrp1 is initiated by the binding of feeding-specific ligand(s) to Hk1 sensor domain D1 and/or D2. Once activated, Rrp1 directs the synthesis of cyclic dimeric GMP (c-di-GMP), which, in turn, modulates the expression and/or activity of gene products required for survival within feeding ticks. In contrast to the Rrp2/RpoN/RpoS pathway, which is active only within feeding nymphs, the Hk1/Rrp1 TCS is essential for survival during both larval and nymphal blood meals." @default.
- W2101665157 created "2016-06-24" @default.
- W2101665157 creator A5006241823 @default.
- W2101665157 creator A5008416064 @default.
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- W2101665157 creator A5024387344 @default.
- W2101665157 creator A5047608004 @default.
- W2101665157 creator A5052457700 @default.
- W2101665157 creator A5063378058 @default.
- W2101665157 creator A5070150746 @default.
- W2101665157 creator A5073503247 @default.
- W2101665157 date "2011-08-01" @default.
- W2101665157 modified "2023-10-09" @default.
- W2101665157 title "The Hybrid Histidine Kinase Hk1 Is Part of a Two-Component System That Is Essential for Survival of Borrelia burgdorferi in Feeding Ixodes scapularis Ticks" @default.
- W2101665157 cites W1535820401 @default.
- W2101665157 cites W1544627009 @default.
- W2101665157 cites W1557420229 @default.
- W2101665157 cites W1561561510 @default.
- W2101665157 cites W1608403029 @default.
- W2101665157 cites W1862461099 @default.
- W2101665157 cites W1911163705 @default.
- W2101665157 cites W1926303070 @default.
- W2101665157 cites W1963867445 @default.
- W2101665157 cites W1969762827 @default.
- W2101665157 cites W1971997807 @default.
- W2101665157 cites W1976511855 @default.
- W2101665157 cites W1977904572 @default.
- W2101665157 cites W1986984168 @default.
- W2101665157 cites W1993560924 @default.
- W2101665157 cites W1994028292 @default.
- W2101665157 cites W1997450290 @default.
- W2101665157 cites W2003173053 @default.
- W2101665157 cites W2004938907 @default.
- W2101665157 cites W2006304581 @default.
- W2101665157 cites W2006909053 @default.
- W2101665157 cites W2014754473 @default.
- W2101665157 cites W2017047316 @default.
- W2101665157 cites W2019962465 @default.
- W2101665157 cites W2026477069 @default.
- W2101665157 cites W2027296251 @default.
- W2101665157 cites W2032514386 @default.
- W2101665157 cites W2035946377 @default.
- W2101665157 cites W2039330229 @default.
- W2101665157 cites W2043454090 @default.
- W2101665157 cites W2047283050 @default.
- W2101665157 cites W2055735551 @default.
- W2101665157 cites W2064858518 @default.
- W2101665157 cites W2069715508 @default.
- W2101665157 cites W2070418462 @default.
- W2101665157 cites W2073075400 @default.
- W2101665157 cites W2080758220 @default.
- W2101665157 cites W2082643262 @default.
- W2101665157 cites W2086323657 @default.
- W2101665157 cites W2088837736 @default.
- W2101665157 cites W2088926839 @default.
- W2101665157 cites W2089846493 @default.
- W2101665157 cites W2090093881 @default.
- W2101665157 cites W2093772258 @default.
- W2101665157 cites W2097207216 @default.
- W2101665157 cites W2103025674 @default.
- W2101665157 cites W2106882534 @default.
- W2101665157 cites W2106923147 @default.
- W2101665157 cites W2107093868 @default.
- W2101665157 cites W2108432812 @default.
- W2101665157 cites W2109874283 @default.
- W2101665157 cites W2111489112 @default.
- W2101665157 cites W2111701441 @default.
- W2101665157 cites W2112984193 @default.
- W2101665157 cites W2113273019 @default.
- W2101665157 cites W2116073343 @default.
- W2101665157 cites W2116128404 @default.
- W2101665157 cites W2116755292 @default.
- W2101665157 cites W2121033175 @default.
- W2101665157 cites W2121386707 @default.
- W2101665157 cites W2123757128 @default.
- W2101665157 cites W2125112034 @default.
- W2101665157 cites W2125366409 @default.
- W2101665157 cites W2126383924 @default.
- W2101665157 cites W2126830973 @default.
- W2101665157 cites W2130913568 @default.
- W2101665157 cites W2133662578 @default.
- W2101665157 cites W2135278450 @default.
- W2101665157 cites W2138059406 @default.
- W2101665157 cites W2139262548 @default.
- W2101665157 cites W2141059784 @default.
- W2101665157 cites W2143543126 @default.
- W2101665157 cites W2145741346 @default.
- W2101665157 cites W2149784756 @default.
- W2101665157 cites W2150491501 @default.
- W2101665157 cites W2151239002 @default.
- W2101665157 cites W2152301430 @default.
- W2101665157 cites W2154379876 @default.
- W2101665157 cites W2160709029 @default.
- W2101665157 cites W2168421163 @default.
- W2101665157 cites W2168486884 @default.
- W2101665157 cites W2170069130 @default.
- W2101665157 cites W4229726285 @default.
- W2101665157 doi "https://doi.org/10.1128/iai.05136-11" @default.