Matches in SemOpenAlex for { <https://semopenalex.org/work/W2101665191> ?p ?o ?g. }
- W2101665191 endingPage "1093" @default.
- W2101665191 startingPage "1085" @default.
- W2101665191 abstract "Mismatch repair systems correct replication- and recombination-associated mispaired bases and influence the stability of simple repeats. These systems thus serve multiple roles in maintaining genetic stability in eukaryotes, and human mismatch repair defects have been associated with hereditary predisposition to cancer. In prokaryotes, mismatch repair systems also have been shown to limit recombination between diverged (homologous) sequences. We have developed a unique intron-based assay system to examine the effects of yeast mismatch repair genes (PMS1, MSH2, and MSH3) on crossovers between homologous sequences. We find that the apparent antirecombination effects of mismatch repair proteins in mitosis are related to the degree of substrate divergence. Defects in mismatch repair can elevate homologous recombination between 91% homologous substrates as much as 100-fold while having only modest effects on recombination between 77% homologous substrates. These observations have implications for genome stability and general mechanisms of recombination in eukaryotes." @default.
- W2101665191 created "2016-06-24" @default.
- W2101665191 creator A5034795112 @default.
- W2101665191 creator A5070829834 @default.
- W2101665191 creator A5072751549 @default.
- W2101665191 creator A5079578493 @default.
- W2101665191 creator A5083808144 @default.
- W2101665191 date "1996-03-01" @default.
- W2101665191 modified "2023-10-11" @default.
- W2101665191 title "Mitotic Crossovers between Diverged Sequences Are Regulated by Mismatch Repair Proteins in <i>Saccharomyces cerevisiae</i>" @default.
- W2101665191 cites W1533214975 @default.
- W2101665191 cites W1547269929 @default.
- W2101665191 cites W1559808711 @default.
- W2101665191 cites W1589404281 @default.
- W2101665191 cites W161746494 @default.
- W2101665191 cites W1798017247 @default.
- W2101665191 cites W1833842636 @default.
- W2101665191 cites W1841455434 @default.
- W2101665191 cites W1862994794 @default.
- W2101665191 cites W1898875758 @default.
- W2101665191 cites W1903900184 @default.
- W2101665191 cites W1965876012 @default.
- W2101665191 cites W1971123159 @default.
- W2101665191 cites W1973782344 @default.
- W2101665191 cites W1977284533 @default.
- W2101665191 cites W1983811214 @default.
- W2101665191 cites W1987664752 @default.
- W2101665191 cites W1988875152 @default.
- W2101665191 cites W1989277854 @default.
- W2101665191 cites W1994822016 @default.
- W2101665191 cites W1997038017 @default.
- W2101665191 cites W2009310436 @default.
- W2101665191 cites W2011719683 @default.
- W2101665191 cites W2012867725 @default.
- W2101665191 cites W2013735712 @default.
- W2101665191 cites W2014571977 @default.
- W2101665191 cites W2016544300 @default.
- W2101665191 cites W2019932549 @default.
- W2101665191 cites W202706838 @default.
- W2101665191 cites W2029099397 @default.
- W2101665191 cites W2030616232 @default.
- W2101665191 cites W2034252391 @default.
- W2101665191 cites W2036463521 @default.
- W2101665191 cites W2039780853 @default.
- W2101665191 cites W2053827853 @default.
- W2101665191 cites W2057594190 @default.
- W2101665191 cites W2062269069 @default.
- W2101665191 cites W2064700784 @default.
- W2101665191 cites W2068705979 @default.
- W2101665191 cites W2069050874 @default.
- W2101665191 cites W2070333996 @default.
- W2101665191 cites W2076629799 @default.
- W2101665191 cites W2077706229 @default.
- W2101665191 cites W2108294716 @default.
- W2101665191 cites W2114171007 @default.
- W2101665191 cites W2114968751 @default.
- W2101665191 cites W2128884353 @default.
- W2101665191 cites W2139964075 @default.
- W2101665191 cites W2152170859 @default.
- W2101665191 cites W2152693329 @default.
- W2101665191 cites W2156894395 @default.
- W2101665191 cites W2159386589 @default.
- W2101665191 cites W2169333620 @default.
- W2101665191 cites W2185950865 @default.
- W2101665191 cites W2200339783 @default.
- W2101665191 cites W2242861315 @default.
- W2101665191 cites W2503367931 @default.
- W2101665191 cites W4240065971 @default.
- W2101665191 cites W4253664160 @default.
- W2101665191 cites W4254536048 @default.
- W2101665191 cites W2010088549 @default.
- W2101665191 doi "https://doi.org/10.1128/mcb.16.3.1085" @default.
- W2101665191 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/231091" @default.
- W2101665191 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8622653" @default.
- W2101665191 hasPublicationYear "1996" @default.
- W2101665191 type Work @default.
- W2101665191 sameAs 2101665191 @default.
- W2101665191 citedByCount "206" @default.
- W2101665191 countsByYear W21016651912012 @default.
- W2101665191 countsByYear W21016651912013 @default.
- W2101665191 countsByYear W21016651912014 @default.
- W2101665191 countsByYear W21016651912015 @default.
- W2101665191 countsByYear W21016651912016 @default.
- W2101665191 countsByYear W21016651912017 @default.
- W2101665191 countsByYear W21016651912018 @default.
- W2101665191 countsByYear W21016651912019 @default.
- W2101665191 countsByYear W21016651912020 @default.
- W2101665191 countsByYear W21016651912021 @default.
- W2101665191 countsByYear W21016651912022 @default.
- W2101665191 countsByYear W21016651912023 @default.
- W2101665191 crossrefType "journal-article" @default.
- W2101665191 hasAuthorship W2101665191A5034795112 @default.
- W2101665191 hasAuthorship W2101665191A5070829834 @default.
- W2101665191 hasAuthorship W2101665191A5072751549 @default.
- W2101665191 hasAuthorship W2101665191A5079578493 @default.
- W2101665191 hasAuthorship W2101665191A5083808144 @default.
- W2101665191 hasBestOaLocation W21016651911 @default.
- W2101665191 hasConcept C104317684 @default.