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• W2101673374 endingPage "152" @default.
• W2101673374 startingPage "145" @default.
• W2101673374 abstract "Incretin-based therapies exploit the insulinotropic actions of the gut hormones gastric inhibitory peptide (GIP) and glucagon-like peptide-1 (GLP-1) for the treatment of diabetes and include GLP-1 receptor agonists and inhibitors of dipeptidyl peptidase-4 (DPP-4), the enzyme that inactivates the incretin hormones in the body. Both drug classes improve metabolic control in type 2 diabetes (T2DM), with GLP-1 receptor agonists also lowering body weight. Pharmacotherapy using DPP-4 inhibitors has few side effects and is weight neutral. Animal studies support their use in prediabetes; however, human data are scarce. GLP-1 receptor agonist effects are also apparent in non-diabetic obese individuals. Therefore, incretin-based therapies, if safe, may be effective in preventing progression of prediabetes; and GLP-1 receptor agonists may have potential for use in the treatment of obesity." @default.
• W2101673374 created "2016-06-24" @default.
• W2101673374 creator A5054335526 @default.
• W2101673374 creator A5085434984 @default.
• W2101673374 date "2013-03-01" @default.
• W2101673374 modified "2023-09-23" @default.
• W2101673374 title "Is there a place for incretin therapies in obesity and prediabetes?" @default.
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