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- W2101678203 abstract "Abstract. The results of 131 I treatment in combination with pre- and post-treatment with carbimazole (n = 122) were compared to the results of 131 I used as the only antithyroid treatment (n = 203). The two groups of patients were fully comparable in regard to age, size of goitre and time of observation, and the same diagnostic criteria and dosage regimen of 131 I were used. The incidence of early myxoedema in patients with diffuse goitre was significantly reduced after combination therapy, 5 per cent, compared to 16 per cent after 131 I as the only antithyroid therapy ( P < 0.05). The incidence of late myxoedema was 6 per cent in both groups 3 years after the last treatment, and fully compensated myxoedema was found in 13 and 22 per cent (n.s.). No severe acute side effects were observed after 131 I therapy in any of the two groups. It is concluded that - in diffuse toxic goitre - a lower early incidence of myxoedema was obtained on the combined regimen because of either a possibly lower absorbed radiation dose or a more fractionate therapy. A major advantage of the combination therapy is also, that the patients are rendered euthyroid shortly after the diagnosis and remain so during the prolonged period of treatment. 131 I treatment in combination with carbimazole is advocated in all patients with diffuse and nodular toxic goitre if the patient is above fertile age and thyroidectomy is not indicated." @default.
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- W2101678203 date "1982-04-01" @default.
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- W2101678203 title "131I treatment of diffuse and nodular toxic goitre with or without antithyroid agents" @default.
- W2101678203 doi "https://doi.org/10.1530/acta.0.0990517" @default.
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