FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2101681489> ?p ?o ?g. }

• W2101681489 endingPage "2304" @default.
• W2101681489 startingPage "2299" @default.
• W2101681489 abstract "Previous studies have suggested that liver cell proliferation is fundamental for the growth of carcinogen-initiated cells. To gain further information on the association between cell proliferation and hepatocarcinogenesis, we have examined the effect of the hormone 3,3′,5-triiodo-L-thyronine (T3), a strong liver mitogen, on the growth of diethylnitrosamine (DENA)-induced hepatic lesions positive for the placental form of glutathione S -transferase (GSTP). Two weeks after a single initiating dose of DENA (150 mg/kg), cycles of liver cell proliferation were induced in male Fischer rats by feeding a T3-supplemented diet (4 mg/kg) 1 week/month for 7 months. Rats were killed at the end of the seventh cycle or 1 month later. Results indicate that, in spite of an increased labelling index, a 70% reduction in the number/cm 2 of GSTP-positive minifoci occurred in T3-treated rats. A decrease in the number of GSTP-positive foci was also observed in T3-treated rats killed 1 month after the last exposure to the hormone (40, versus 67 foci/cm 2 in controls), indicating that the reduction was not due to an inhibitory effect on GSTP exerted by the concomitant presence of T3. In a second series of experiments where DENA-treated rats were fed T3 for 1 week and then subjected to the resistant hepatocyte (RH) model, it was found that T3 treatment prior to promotion resulted in a decrease in the number of GSTP-positive foci (16 GSTP + foci/cm 2 in T3-fed animals versus 45 in the control group). The results indicate that cell proliferation associated with T3 treatment: (i) reduces the number of carcinogen-induced GSTP-positive lesions; (ii) does not exert any differential effect on the growth of the remaining foci; (iii) inhibits the capacity of putative DENA-initiated cells to be promoted by the RH model. Data suggest that cell proliferation may not necessarily represent a stimulus for the growth of putative preneoplastic lesions." @default.
• W2101681489 created "2016-06-24" @default.
• W2101681489 creator A5000181906 @default.
• W2101681489 creator A5002615996 @default.
• W2101681489 creator A5019089427 @default.
• W2101681489 creator A5023001943 @default.
• W2101681489 creator A5024911981 @default.
• W2101681489 creator A5051424046 @default.
• W2101681489 creator A5075111038 @default.
• W2101681489 date "1999-12-01" @default.
• W2101681489 modified "2023-10-10" @default.
• W2101681489 title "Cell proliferation induced by 3,3′,5-triiodo-L-thyronine is associated with a reduction in the number of preneoplastic hepatic lesions" @default.
• W2101681489 cites W1562053774 @default.
• W2101681489 cites W1572545031 @default.
• W2101681489 cites W1581333745 @default.
• W2101681489 cites W1906197854 @default.
• W2101681489 cites W1969484786 @default.
• W2101681489 cites W1970218284 @default.
• W2101681489 cites W1973987325 @default.
• W2101681489 cites W1984442252 @default.
• W2101681489 cites W1996725840 @default.
• W2101681489 cites W1998226622 @default.
• W2101681489 cites W2005381573 @default.
• W2101681489 cites W2005928284 @default.
• W2101681489 cites W2013229430 @default.
• W2101681489 cites W2024230068 @default.
• W2101681489 cites W2025421728 @default.
• W2101681489 cites W2034231350 @default.
• W2101681489 cites W2041154904 @default.
• W2101681489 cites W2043493252 @default.
• W2101681489 cites W2062510470 @default.
• W2101681489 cites W2095469145 @default.
• W2101681489 cites W2132969614 @default.
• W2101681489 cites W2153627541 @default.
• W2101681489 cites W2164622029 @default.
• W2101681489 cites W2168109557 @default.
• W2101681489 cites W2168300082 @default.
• W2101681489 cites W2169461560 @default.
• W2101681489 cites W2252609745 @default.
• W2101681489 cites W2323393387 @default.
• W2101681489 cites W2323654339 @default.
• W2101681489 cites W4211173486 @default.
• W2101681489 doi "https://doi.org/10.1093/carcin/20.12.2299" @default.
• W2101681489 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10590223" @default.
• W2101681489 hasPublicationYear "1999" @default.
• W2101681489 type Work @default.
• W2101681489 sameAs 2101681489 @default.
• W2101681489 citedByCount "24" @default.
• W2101681489 countsByYear W21016814892013 @default.
• W2101681489 countsByYear W21016814892016 @default.
• W2101681489 countsByYear W21016814892017 @default.
• W2101681489 countsByYear W21016814892018 @default.
• W2101681489 countsByYear W21016814892019 @default.
• W2101681489 crossrefType "journal-article" @default.
• W2101681489 hasAuthorship W2101681489A5000181906 @default.
• W2101681489 hasAuthorship W2101681489A5002615996 @default.
• W2101681489 hasAuthorship W2101681489A5019089427 @default.
• W2101681489 hasAuthorship W2101681489A5023001943 @default.
• W2101681489 hasAuthorship W2101681489A5024911981 @default.
• W2101681489 hasAuthorship W2101681489A5051424046 @default.
• W2101681489 hasAuthorship W2101681489A5075111038 @default.
• W2101681489 hasBestOaLocation W21016814891 @default.
• W2101681489 hasConcept C114246631 @default.
• W2101681489 hasConcept C121608353 @default.
• W2101681489 hasConcept C126322002 @default.
• W2101681489 hasConcept C134018914 @default.
• W2101681489 hasConcept C181199279 @default.
• W2101681489 hasConcept C185592680 @default.
• W2101681489 hasConcept C202751555 @default.
• W2101681489 hasConcept C2776200302 @default.
• W2101681489 hasConcept C2778260397 @default.
• W2101681489 hasConcept C2778288131 @default.
• W2101681489 hasConcept C2779074563 @default.
• W2101681489 hasConcept C2779384505 @default.
• W2101681489 hasConcept C2780122803 @default.
• W2101681489 hasConcept C29730261 @default.
• W2101681489 hasConcept C538909803 @default.
• W2101681489 hasConcept C55493867 @default.
• W2101681489 hasConcept C555283112 @default.
• W2101681489 hasConcept C62112901 @default.
• W2101681489 hasConcept C71315377 @default.
• W2101681489 hasConcept C71924100 @default.
• W2101681489 hasConcept C86803240 @default.
• W2101681489 hasConceptScore W2101681489C114246631 @default.
• W2101681489 hasConceptScore W2101681489C121608353 @default.
• W2101681489 hasConceptScore W2101681489C126322002 @default.
• W2101681489 hasConceptScore W2101681489C134018914 @default.
• W2101681489 hasConceptScore W2101681489C181199279 @default.
• W2101681489 hasConceptScore W2101681489C185592680 @default.
• W2101681489 hasConceptScore W2101681489C202751555 @default.
• W2101681489 hasConceptScore W2101681489C2776200302 @default.
• W2101681489 hasConceptScore W2101681489C2778260397 @default.
• W2101681489 hasConceptScore W2101681489C2778288131 @default.
• W2101681489 hasConceptScore W2101681489C2779074563 @default.
• W2101681489 hasConceptScore W2101681489C2779384505 @default.
• W2101681489 hasConceptScore W2101681489C2780122803 @default.
• W2101681489 hasConceptScore W2101681489C29730261 @default.
• W2101681489 hasConceptScore W2101681489C538909803 @default.

• next