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• W2101749166 abstract "Research Article1 April 1993free access A mitochondrial import factor purified from rat liver cytosol is an ATP-dependent conformational modulator for precursor proteins. N. Hachiya N. Hachiya Department of Molecular Biology, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan. Search for more papers by this author R. Alam R. Alam Department of Molecular Biology, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan. Search for more papers by this author Y. Sakasegawa Y. Sakasegawa Department of Molecular Biology, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan. Search for more papers by this author M. Sakaguchi M. Sakaguchi Department of Molecular Biology, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan. Search for more papers by this author K. Mihara K. Mihara Department of Molecular Biology, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan. Search for more papers by this author T. Omura T. Omura Department of Molecular Biology, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan. Search for more papers by this author N. Hachiya N. Hachiya Department of Molecular Biology, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan. Search for more papers by this author R. Alam R. Alam Department of Molecular Biology, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan. Search for more papers by this author Y. Sakasegawa Y. Sakasegawa Department of Molecular Biology, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan. Search for more papers by this author M. Sakaguchi M. Sakaguchi Department of Molecular Biology, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan. Search for more papers by this author K. Mihara K. Mihara Department of Molecular Biology, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan. Search for more papers by this author T. Omura T. Omura Department of Molecular Biology, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan. Search for more papers by this author Author Information N. Hachiya1, R. Alam1, Y. Sakasegawa1, M. Sakaguchi1, K. Mihara1 and T. Omura1 1Department of Molecular Biology, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan. The EMBO Journal (1993)12:1579-1586https://doi.org/10.1002/j.1460-2075.1993.tb05802.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info Rat liver cytosol contained an activity that stimulated the import of wheat germ lysate-synthesized precursor proteins into mitochondria. The activity was purified 10,000-fold from the cytosol as a homogeneous heterodimeric protein. This protein (termed mitochondrial import stimulation factor or MSF) stimulated the binding and import of mitochondrial precursor proteins. MSF was also found to recognize the presequence portion of mitochondrial precursors and catalyze the depolymerization and unfolding of in vitro synthesized mitochondrial precursor proteins in an ATP-dependent manner; in this connection, MSF exhibited ATPase activity depending on the important-incompetent mitochondrial precursor protein. The mitochondrial binding and import-stimulating activities were strongly inhibited by the pretreatment of MSF with NEM, whereas the ATP-dependent depolymerization activity was insensitive to the NEM treatment, suggesting that the process subsequent to the unfolding was inhibited with the NEM treatment. We conclude that MSF is a multifunctional cytoplasmic chaperone specific for mitochondrial protein import. Previous ArticleNext Article Volume 12Issue 41 April 1993In this issue RelatedDetailsLoading ..." @default.
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• W2101749166 title "A mitochondrial import factor purified from rat liver cytosol is an ATP-dependent conformational modulator for precursor proteins." @default.
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