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- W2101760401 abstract "Brain Derived Neurotrophic Factor (BDNF) is a neurotrophin with important functions in neuronal development and neuroplasticity. Accumulating evidence suggests that alterations in BDNF expression levels underlie a variety of psychiatric and neurological disorders. Indeed, BDNF therapies are currently being investigated in animal models and clinical studies. However, very little is currently known about the mechanisms that deregulate BDNF gene expression in these disorders. The BDNF gene structure and tissue expression pattern is complex, controlled in humans by 9 different gene promoters. Recently, epigenetic changes at the BDNF gene locus have been proposed to provide a link between gene and environment. In this review, we will summarize the current knowledge of BDNF epigenetic regulation with respect to psychiatric disorders and describe how this information can be applied in therapy and future research." @default.
- W2101760401 created "2016-06-24" @default.
- W2101760401 creator A5007633933 @default.
- W2101760401 creator A5064747782 @default.
- W2101760401 date "2014-10-01" @default.
- W2101760401 modified "2023-09-30" @default.
- W2101760401 title "Brain derived neurotrophic factor: Epigenetic regulation in psychiatric disorders" @default.
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- W2101760401 doi "https://doi.org/10.1016/j.brainres.2014.06.037" @default.
- W2101760401 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25223903" @default.
- W2101760401 hasPublicationYear "2014" @default.
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