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- W2101765956 abstract "HIV-1 is able to infect nondividing cells productively in part because the postentry viral nucleoprotein complexes are actively imported into the nucleus. In this manuscript, we identify a novel nuclear localization signal (NLS) in the viral integrase (IN) protein that is essential for virus replication in both dividing and nondividing cells. The IN NLS stimulates the efficient nuclear accumulation of viral DNA as well as virion-derived IN protein during the initial stages of infection but is dispensable for catalytic function. Because this NLS is required for infection irrespective of target cell proliferation, we suggest that interactions between uncoated viral nucleoprotein complexes and the host cell nuclear import machinery are critical for HIV-1 infection of all cells." @default.
- W2101765956 created "2016-06-24" @default.
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- W2101765956 date "2001-05-01" @default.
- W2101765956 modified "2023-10-14" @default.
- W2101765956 title "HIV-1 Infection Requires a Functional Integrase NLS" @default.
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- W2101765956 doi "https://doi.org/10.1016/s1097-2765(01)00240-4" @default.
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