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• W2101783669 abstract "Abstract Donor‐reactive memory T cells present a special hurdle in transplantation. Although hematopoietic chimerism is effective for inducing donor‐specific tolerance, the effects on memory T cells are unclear. Here, we induced stable chimerism and tolerance in mice (Tolerance group, n = 6) by donor‐specific transfusion (DST) plus anti‐CD154 monoclonal antibody (mAb), avoiding the toxic myeloablative conditioning treatment to assist bone marrow transplantation (DST/aCD154&BMTx). We then transferred memory CD4 + or CD8 + T cells from donor antigen primed mice to the tolerance‐induced recipients 4 days after heart transplantation (Tol/CD4 + Tm group and Tol/CD8 + Tm group, n = 6, respectively), but neither of these memory T‐cell subsets had an effect on the permanent graft survival (median survival time > 100 days). The unaltered rate of memory T cells in spleen and anergy to donor antigen in vitro demonstrated that these memory T cells were well controlled. The chimerism‐promoting protocol DST/aCD154&BMTx produced an immune environment that included high levels of regulatory T cells (Tregs), microchimerism and TGF‐β, all of which may act in suppressing the donor‐reactive memory CD4 + or CD8 + T cells. These findings have potentially important implications for designing approaches to suppressing memory T cells for success of transplantation." @default.
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• W2101783669 date "2010-07-06" @default.
• W2101783669 modified "2023-10-15" @default.
• W2101783669 title "Inhibition of Alloantigen-Primed Memory CD4+ and CD8+ T Cells by Hematopoietic Chimerism in Mice" @default.
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• W2101783669 doi "https://doi.org/10.1111/j.1365-3083.2010.02412.x" @default.
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