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• W2101791248 startingPage "152" @default.
• W2101791248 abstract "AbstractBackground: Anaphylaxis after ingestion of spices as a result from occupational sensitization remains anecdotal. We describe a patient, working in a spice factory, with anaphylaxis from coriander in a meal. He also demonstrated urticaria, angio-edema, rhinoconjunctivitis and bronchospasm during handling coriander and fenugreek.Objective: To determine the mechanism of the anaphylactic reaction and to evaluate cross-reactivity between both botanically unrelated spices.Methods: Investigations comprised quantification of total and specific IgE by Immuno-CAP FEIA, skin testing, basophil activation experiments by flow-assisted determination of CD63 expression in the patient and 3 healthy controls. Immuno-CAP inhibition experiments were applied to investigate cross-reactivity.Results: Specific IgE, skin tests and basophil activation tests were clearly positive in the patient, whereas they remained negative in controls. No cross-reactivity between fenugreek and coriander was demonstrable by inhibition experiments.Conclusions: The clinical manifestations in temporal relationship to ingestion of coriander and handling of coriander and/or fenugreek, the positive specific IgE results, skin tests and basophil activation assays support the diagnosis of allergy to both spices. History suggests sensitization by occupational exposure.Keywords: anaphylaxisCD63corianderfenugreekflow cytometryoccupational allergy" @default.
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• W2101791248 date "2006-06-01" @default.
• W2101791248 modified "2023-10-18" @default.
• W2101791248 title "CORIANDER ANAPHYLAXIS IN A SPICE GRINDER WITH UNDETECTED OCCUPATIONAL ALLERGY" @default.
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• W2101791248 doi "https://doi.org/10.1179/acb.2006.025" @default.
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