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• W2101792238 abstract "The already obvious clinical need to try to overcome the prob? lems of self administration of medicaments,16 supported by a scientific basis,42 led us to explore the efficacy and acceptability of intermittent regimens based on twice weekly or once weekly treatment with isoniazid and streptomycin in Madras.6 7 Subsequently Mitchison and Dickinson43 showed that single pulses of bactericidal drugs could inhibit all division of bacilli for several days. A key community study, which began in 1967 in the central Bohemian region of Czechoslovakia, surrounding Prague, compared in outpatients twice weekly streptomycin plus isoniazid and daily isoniazid plus PAS, both after an initial daily phase of three drugs in hospital. The supervised inter? mittent regimen proved to be as effective therapeutically as the widely used unsupervised daily regimen.44 46 This conclusion was confirmed in a controlled trial in Britain,47 and in Singapore the intermittent regimen was rather better than the oral combination.48 Supervised intermittent chemotherapy was therefore shown to be an effective alternative system to self administered oral regimens. Moreover, it improves the control of chemotherapy, reduces the risk of drug toxicity, and sub? stantially lowers the cost of the drugs.41 An integral part of the organisation of the supervised inter? mittent regimens in Czechoslovakia was to make the arrange? ments as flexible as possible, our aim being to suit the conveni? ence of the patients so that there would be as little disruption as possible of their normal lives.44 Thus patients could choose to" @default.
• W2101792238 created "2016-06-24" @default.
• W2101792238 creator A5054192875 @default.
• W2101792238 date "1983-07-09" @default.
• W2101792238 modified "2023-09-25" @default.
• W2101792238 title "Compliance of patients and physicians: experience and lessons from tuberculosis-II." @default.
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• W2101792238 doi "https://doi.org/10.1136/bmj.287.6385.101" @default.
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