FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2101804578> ?p ?o ?g. }

• W2101804578 endingPage "3885" @default.
• W2101804578 startingPage "3875" @default.
• W2101804578 abstract "The Saccharomyces cerevisiae ubiquitin ligase SCF(Met30) is essential for cell cycle progression. To identify and characterize SCF(Met30)-dependent cell cycle steps, we used temperature-sensitive met30 mutants in cell cycle synchrony experiments. These experiments revealed a requirement for Met30 during both G(1)/S transition and M phase, while progression through S phase was unaffected by loss of Met30 function. Expression of the G(1)-specific transcripts CLN1, CLN2, and CLB5 was very low in met30 mutants, whereas expression of CLN3 was unaffected. However, overexpression of Cln2 could not overcome the G(1) arrest. Interestingly, overexpression of Clb5 could induce DNA replication in met30 mutants, albeit very inefficiently. Increased levels of Clb5 could not, however, suppress the cell proliferation defect of met30 mutants. Consistent with the DNA replication defects, chromatin immunoprecipitation experiments revealed significantly lower levels of the replication factors Mcm4, Mcm7, and Cdc45 at replication origins in met30 mutants than in wild-type cells. These data suggest that Met30 regulates several aspects of the cell cycle, including G(1)-specific transcription, initiation of DNA replication, and progression through M phase." @default.
• W2101804578 created "2016-06-24" @default.
• W2101804578 creator A5055683748 @default.
• W2101804578 creator A5062034794 @default.
• W2101804578 creator A5076851587 @default.
• W2101804578 date "2005-05-01" @default.
• W2101804578 modified "2023-10-11" @default.
• W2101804578 title "The F-Box Protein Met30 Is Required for Multiple Steps in the Budding Yeast Cell Cycle" @default.
• W2101804578 cites W169216998 @default.
• W2101804578 cites W1778446120 @default.
• W2101804578 cites W1871042223 @default.
• W2101804578 cites W1884388113 @default.
• W2101804578 cites W1966034049 @default.
• W2101804578 cites W1972139510 @default.
• W2101804578 cites W1978217568 @default.
• W2101804578 cites W1982290796 @default.
• W2101804578 cites W1985225337 @default.
• W2101804578 cites W1987339939 @default.
• W2101804578 cites W1992220084 @default.
• W2101804578 cites W1997973407 @default.
• W2101804578 cites W1998257113 @default.
• W2101804578 cites W2001994073 @default.
• W2101804578 cites W2002315746 @default.
• W2101804578 cites W2009559661 @default.
• W2101804578 cites W2015038174 @default.
• W2101804578 cites W2033228162 @default.
• W2101804578 cites W2042827497 @default.
• W2101804578 cites W2043038579 @default.
• W2101804578 cites W2046707499 @default.
• W2101804578 cites W2047693210 @default.
• W2101804578 cites W2060458509 @default.
• W2101804578 cites W2064249717 @default.
• W2101804578 cites W2074126694 @default.
• W2101804578 cites W2075205928 @default.
• W2101804578 cites W2075408326 @default.
• W2101804578 cites W2078477504 @default.
• W2101804578 cites W2078906089 @default.
• W2101804578 cites W2093330988 @default.
• W2101804578 cites W2094923559 @default.
• W2101804578 cites W2096376310 @default.
• W2101804578 cites W2098072005 @default.
• W2101804578 cites W2106130068 @default.
• W2101804578 cites W2121781216 @default.
• W2101804578 cites W2128469130 @default.
• W2101804578 cites W2160256138 @default.
• W2101804578 cites W2165934569 @default.
• W2101804578 cites W2166219128 @default.
• W2101804578 cites W2166987747 @default.
• W2101804578 cites W2168662100 @default.
• W2101804578 cites W2170634115 @default.
• W2101804578 cites W2308586243 @default.
• W2101804578 cites W2603569803 @default.
• W2101804578 cites W4246932843 @default.
• W2101804578 cites W4253267727 @default.
• W2101804578 cites W55455380 @default.
• W2101804578 doi "https://doi.org/10.1128/mcb.25.10.3875-3885.2005" @default.
• W2101804578 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1087702" @default.
• W2101804578 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15870262" @default.
• W2101804578 hasPublicationYear "2005" @default.
• W2101804578 type Work @default.
• W2101804578 sameAs 2101804578 @default.
• W2101804578 citedByCount "25" @default.
• W2101804578 countsByYear W21018045782012 @default.
• W2101804578 countsByYear W21018045782013 @default.
• W2101804578 countsByYear W21018045782018 @default.
• W2101804578 countsByYear W21018045782019 @default.
• W2101804578 countsByYear W21018045782020 @default.
• W2101804578 countsByYear W21018045782021 @default.
• W2101804578 crossrefType "journal-article" @default.
• W2101804578 hasAuthorship W2101804578A5055683748 @default.
• W2101804578 hasAuthorship W2101804578A5062034794 @default.
• W2101804578 hasAuthorship W2101804578A5076851587 @default.
• W2101804578 hasBestOaLocation W21018045782 @default.
• W2101804578 hasConcept C104317684 @default.
• W2101804578 hasConcept C104690221 @default.
• W2101804578 hasConcept C134459356 @default.
• W2101804578 hasConcept C1491633281 @default.
• W2101804578 hasConcept C151158763 @default.
• W2101804578 hasConcept C25602115 @default.
• W2101804578 hasConcept C29537977 @default.
• W2101804578 hasConcept C41141232 @default.
• W2101804578 hasConcept C54355233 @default.
• W2101804578 hasConcept C552990157 @default.
• W2101804578 hasConcept C73573662 @default.
• W2101804578 hasConcept C83640560 @default.
• W2101804578 hasConcept C86803240 @default.
• W2101804578 hasConcept C95444343 @default.
• W2101804578 hasConcept C98086919 @default.
• W2101804578 hasConceptScore W2101804578C104317684 @default.
• W2101804578 hasConceptScore W2101804578C104690221 @default.
• W2101804578 hasConceptScore W2101804578C134459356 @default.
• W2101804578 hasConceptScore W2101804578C1491633281 @default.
• W2101804578 hasConceptScore W2101804578C151158763 @default.
• W2101804578 hasConceptScore W2101804578C25602115 @default.
• W2101804578 hasConceptScore W2101804578C29537977 @default.
• W2101804578 hasConceptScore W2101804578C41141232 @default.
• W2101804578 hasConceptScore W2101804578C54355233 @default.
• W2101804578 hasConceptScore W2101804578C552990157 @default.

• next