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- W2101830810 abstract "In radiotherapy, clinical dose-control curves are generally more shallow than what should be expected from in vitro dose-survival curves for human cells of the same histology. One possible explanation is that a considerable inter-tumor heterogeneity in radiosensitivity flattens out the presumably steep individual dose-control curves. This paper compares dose-control curves for malignant melanomas derived from clinical data with curves derived from in vitro cell-survival experiments. Although inter-tumour variability in the in vitro dose and fractionation sensitivity may explain parts of the discrepancy between the steepness of clinical and in vitro dose-control curves, the present calculation indicates that a considerable additional variability, undetected by current in vitro assays, must be assumed to exist in order to resolve the discrepancy." @default.
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- W2101830810 date "1990-01-01" @default.
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- W2101830810 title "Does Variation in the<i>in Vitro</i>Cellular Radiosensitivity Explain the Shallow Clinical Dose—control Curve for Malignant Melanoma?" @default.
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- W2101830810 doi "https://doi.org/10.1080/09553009014550391" @default.
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