FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2101858601> ?p ?o ?g. }

• W2101858601 endingPage "208" @default.
• W2101858601 startingPage "199" @default.
• W2101858601 abstract "Nitric oxide (NO) is synthesized from arginine by NO synthase (NOS), and the availability of arginine is one of the rate-limiting factors in cellular NO production. Arginase catalyzes the hydrolysis of arginine to urea and ornithine. Thus, both NOS and arginase use arginine as a common substrate. Arginase exists in two known isoforms, hepatic cytosolic type (arginase I) and nonhepatic mitochondrial Type (arginase II). Several lines of evidence indicate that arginase competes with NOS for the substrate and downregulates NO production. Inducible NOS (iNOS) and arginase activities are regulated reciprocally in macrophages by cytokines, and this may guarantee the efficient production of NO. When rat peritoneal macrophages are stimulated with bacterial lipopolysaccharide (LPS), iNOS is induced first, followed by arginase I, suggesting that arginase I prevents sustained overproduction of NO. On the other hand, no production in activated macrophages is enhanced by arginase inhibitors. When arginase II is induced, NO production is much decreased, and the cells are rescued from apoptosis. The results indicate that NO production is modulated by arginase isoforms at the level of both activity and enzyme amount in various cell types." @default.
• W2101858601 created "2016-06-24" @default.
• W2101858601 creator A5000776443 @default.
• W2101858601 creator A5036543694 @default.
• W2101858601 date "2000-01-01" @default.
• W2101858601 modified "2023-09-26" @default.
• W2101858601 title "Relationship between Arginase Activity and Nitric Oxide Production" @default.
• W2101858601 cites W124257475 @default.
• W2101858601 cites W1499193548 @default.
• W2101858601 cites W1544794927 @default.
• W2101858601 cites W1563516740 @default.
• W2101858601 cites W1563904830 @default.
• W2101858601 cites W1590474280 @default.
• W2101858601 cites W1602510516 @default.
• W2101858601 cites W1605080122 @default.
• W2101858601 cites W161888996 @default.
• W2101858601 cites W1764308599 @default.
• W2101858601 cites W1889990604 @default.
• W2101858601 cites W1964937890 @default.
• W2101858601 cites W1967041903 @default.
• W2101858601 cites W1969310118 @default.
• W2101858601 cites W1969543607 @default.
• W2101858601 cites W1980077908 @default.
• W2101858601 cites W1984188855 @default.
• W2101858601 cites W1987881651 @default.
• W2101858601 cites W2001810187 @default.
• W2101858601 cites W2003106613 @default.
• W2101858601 cites W2005271042 @default.
• W2101858601 cites W2008685668 @default.
• W2101858601 cites W2009505217 @default.
• W2101858601 cites W2011992952 @default.
• W2101858601 cites W2015192504 @default.
• W2101858601 cites W2018696161 @default.
• W2101858601 cites W2020818523 @default.
• W2101858601 cites W2028505614 @default.
• W2101858601 cites W2029231497 @default.
• W2101858601 cites W2029902056 @default.
• W2101858601 cites W2032875739 @default.
• W2101858601 cites W2036066215 @default.
• W2101858601 cites W2036160471 @default.
• W2101858601 cites W2054191900 @default.
• W2101858601 cites W2056448443 @default.
• W2101858601 cites W2059776433 @default.
• W2101858601 cites W2061006088 @default.
• W2101858601 cites W2065857575 @default.
• W2101858601 cites W2066916400 @default.
• W2101858601 cites W2071705315 @default.
• W2101858601 cites W2071782247 @default.
• W2101858601 cites W2078085754 @default.
• W2101858601 cites W2078796742 @default.
• W2101858601 cites W2087533575 @default.
• W2101858601 cites W2089411383 @default.
• W2101858601 cites W2091675805 @default.
• W2101858601 cites W2091766832 @default.
• W2101858601 cites W2145927192 @default.
• W2101858601 cites W2146191721 @default.
• W2101858601 cites W2171107960 @default.
• W2101858601 cites W2171561094 @default.
• W2101858601 cites W2172219320 @default.
• W2101858601 cites W2339260588 @default.
• W2101858601 cites W2402666566 @default.
• W2101858601 cites W2419604885 @default.
• W2101858601 cites W2767031288 @default.
• W2101858601 doi "https://doi.org/10.1016/b978-012370420-7/50013-7" @default.
• W2101858601 hasPublicationYear "2000" @default.
• W2101858601 type Work @default.
• W2101858601 sameAs 2101858601 @default.
• W2101858601 citedByCount "9" @default.
• W2101858601 countsByYear W21018586012012 @default.
• W2101858601 countsByYear W21018586012017 @default.
• W2101858601 crossrefType "book-chapter" @default.
• W2101858601 hasAuthorship W2101858601A5000776443 @default.
• W2101858601 hasAuthorship W2101858601A5036543694 @default.
• W2101858601 hasConcept C104317684 @default.
• W2101858601 hasConcept C134018914 @default.
• W2101858601 hasConcept C164007495 @default.
• W2101858601 hasConcept C181199279 @default.
• W2101858601 hasConcept C185592680 @default.
• W2101858601 hasConcept C2776796294 @default.
• W2101858601 hasConcept C2777468819 @default.
• W2101858601 hasConcept C2777622882 @default.
• W2101858601 hasConcept C2779129087 @default.
• W2101858601 hasConcept C515207424 @default.
• W2101858601 hasConcept C519581460 @default.
• W2101858601 hasConcept C53345823 @default.
• W2101858601 hasConcept C55493867 @default.
• W2101858601 hasConcept C86803240 @default.
• W2101858601 hasConcept C98539663 @default.
• W2101858601 hasConceptScore W2101858601C104317684 @default.
• W2101858601 hasConceptScore W2101858601C134018914 @default.
• W2101858601 hasConceptScore W2101858601C164007495 @default.
• W2101858601 hasConceptScore W2101858601C181199279 @default.
• W2101858601 hasConceptScore W2101858601C185592680 @default.
• W2101858601 hasConceptScore W2101858601C2776796294 @default.
• W2101858601 hasConceptScore W2101858601C2777468819 @default.
• W2101858601 hasConceptScore W2101858601C2777622882 @default.
• W2101858601 hasConceptScore W2101858601C2779129087 @default.
• W2101858601 hasConceptScore W2101858601C515207424 @default.

• next