FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2101860115> ?p ?o ?g. }

• W2101860115 endingPage "1617" @default.
• W2101860115 startingPage "1609" @default.
• W2101860115 abstract "The human HtrA family of proteases consists of four members: HtrA1, HtrA2, HtrA3, and HtrA4. In humans the four HtrA homologues appear to be involved in several important functions such as cell growth, apoptosis, and inflammatory reactions, and they control cell fate via regulated protein metabolism. In previous studies it was shown that the expression of HtrA1 was ubiquitous in normal adult human tissues. Here we examined the expression of HtrA1 protein and its corresponding mRNA during mouse embryogenesis using Northern blotting hybridization, RT-PCR, and immunohistochemical staining analyses. Our results indicate that HtrA1 is expressed in a variety of tissues in mouse embryos. Furthermore, this expression is regulated in a spatial and temporal manner. Relatively low levels of HtrA1 mRNA are detected in embryos at the beginning of organogenesis (E8), and the levels of expression increase during late organogenesis (E14-E19). Our results show that HtrA1 was expressed during embryonic development in specific areas where signaling by TGFβ family proteins plays important regulatory roles. The expression of HtrA1, documented both at mRNA and protein levels by RT-PCR and immunohistochemistry in the developing nervous system, is consistent with a possible role of this protein both in dividing and postmitotic neurons, possibly via its documented inhibitory effects on TGFβ proteins. An exhaustive knowledge of the different cell- and tissue-specific patterns of expression of HtrA1 in normal mouse embryos is essential for a critical evaluation of the exact role played by this protein during development." @default.
• W2101860115 created "2016-06-24" @default.
• W2101860115 creator A5020924323 @default.
• W2101860115 creator A5024179064 @default.
• W2101860115 creator A5024433864 @default.
• W2101860115 creator A5034288800 @default.
• W2101860115 creator A5043548540 @default.
• W2101860115 creator A5044974615 @default.
• W2101860115 creator A5064623578 @default.
• W2101860115 creator A5076257873 @default.
• W2101860115 creator A5091001750 @default.
• W2101860115 date "2004-12-01" @default.
• W2101860115 modified "2023-09-29" @default.
• W2101860115 title "Pattern of Expression of HtrA1 During Mouse Development" @default.
• W2101860115 cites W1482839084 @default.
• W2101860115 cites W1740666950 @default.
• W2101860115 cites W1966798559 @default.
• W2101860115 cites W1972399597 @default.
• W2101860115 cites W1989009113 @default.
• W2101860115 cites W1991570157 @default.
• W2101860115 cites W1994117795 @default.
• W2101860115 cites W2007608938 @default.
• W2101860115 cites W2024511149 @default.
• W2101860115 cites W2029531329 @default.
• W2101860115 cites W2030613990 @default.
• W2101860115 cites W2031138807 @default.
• W2101860115 cites W2050425919 @default.
• W2101860115 cites W2078222204 @default.
• W2101860115 cites W2084807900 @default.
• W2101860115 cites W2106258762 @default.
• W2101860115 cites W2106870473 @default.
• W2101860115 cites W2114154263 @default.
• W2101860115 cites W2114222892 @default.
• W2101860115 cites W2117612500 @default.
• W2101860115 cites W2147787249 @default.
• W2101860115 cites W2153456878 @default.
• W2101860115 cites W2153689486 @default.
• W2101860115 cites W2159503533 @default.
• W2101860115 doi "https://doi.org/10.1369/jhc.4a6330.2004" @default.
• W2101860115 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15557215" @default.
• W2101860115 hasPublicationYear "2004" @default.
• W2101860115 type Work @default.
• W2101860115 sameAs 2101860115 @default.
• W2101860115 citedByCount "34" @default.
• W2101860115 countsByYear W21018601152012 @default.
• W2101860115 countsByYear W21018601152013 @default.
• W2101860115 countsByYear W21018601152014 @default.
• W2101860115 countsByYear W21018601152016 @default.
• W2101860115 countsByYear W21018601152017 @default.
• W2101860115 countsByYear W21018601152018 @default.
• W2101860115 countsByYear W21018601152020 @default.
• W2101860115 countsByYear W21018601152021 @default.
• W2101860115 crossrefType "journal-article" @default.
• W2101860115 hasAuthorship W2101860115A5020924323 @default.
• W2101860115 hasAuthorship W2101860115A5024179064 @default.
• W2101860115 hasAuthorship W2101860115A5024433864 @default.
• W2101860115 hasAuthorship W2101860115A5034288800 @default.
• W2101860115 hasAuthorship W2101860115A5043548540 @default.
• W2101860115 hasAuthorship W2101860115A5044974615 @default.
• W2101860115 hasAuthorship W2101860115A5064623578 @default.
• W2101860115 hasAuthorship W2101860115A5076257873 @default.
• W2101860115 hasAuthorship W2101860115A5091001750 @default.
• W2101860115 hasConcept C104317684 @default.
• W2101860115 hasConcept C105580179 @default.
• W2101860115 hasConcept C145103041 @default.
• W2101860115 hasConcept C153911025 @default.
• W2101860115 hasConcept C181199279 @default.
• W2101860115 hasConcept C182220744 @default.
• W2101860115 hasConcept C196843134 @default.
• W2101860115 hasConcept C203014093 @default.
• W2101860115 hasConcept C204232928 @default.
• W2101860115 hasConcept C30503417 @default.
• W2101860115 hasConcept C54355233 @default.
• W2101860115 hasConcept C55493867 @default.
• W2101860115 hasConcept C81439078 @default.
• W2101860115 hasConcept C85265743 @default.
• W2101860115 hasConcept C86803240 @default.
• W2101860115 hasConcept C87073359 @default.
• W2101860115 hasConcept C95444343 @default.
• W2101860115 hasConceptScore W2101860115C104317684 @default.
• W2101860115 hasConceptScore W2101860115C105580179 @default.
• W2101860115 hasConceptScore W2101860115C145103041 @default.
• W2101860115 hasConceptScore W2101860115C153911025 @default.
• W2101860115 hasConceptScore W2101860115C181199279 @default.
• W2101860115 hasConceptScore W2101860115C182220744 @default.
• W2101860115 hasConceptScore W2101860115C196843134 @default.
• W2101860115 hasConceptScore W2101860115C203014093 @default.
• W2101860115 hasConceptScore W2101860115C204232928 @default.
• W2101860115 hasConceptScore W2101860115C30503417 @default.
• W2101860115 hasConceptScore W2101860115C54355233 @default.
• W2101860115 hasConceptScore W2101860115C55493867 @default.
• W2101860115 hasConceptScore W2101860115C81439078 @default.
• W2101860115 hasConceptScore W2101860115C85265743 @default.
• W2101860115 hasConceptScore W2101860115C86803240 @default.
• W2101860115 hasConceptScore W2101860115C87073359 @default.
• W2101860115 hasConceptScore W2101860115C95444343 @default.
• W2101860115 hasIssue "12" @default.
• W2101860115 hasLocation W21018601151 @default.

• next