FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2101863176> ?p ?o ?g. }

• W2101863176 endingPage "736" @default.
• W2101863176 startingPage "728" @default.
• W2101863176 abstract "Summary Aims Connexin 43 (Cx43) has been reported to be involved in neuropathic pain, but whether it contributes to morphine antinociceptive tolerance remains unknown. The present study investigated the role of spinal Cx43 in the development of morphine tolerance and its mechanisms in rats. Methods Morphine tolerance was induced by intrathecal (i.t.) administration of morphine (15 μg) daily for seven consecutive days. The analgesia effect was assessed by hot‐water tail‐flick test. Expression of proteins was detected by Western blot and immunohistochemistry assay. Results Chronic morphine markedly increased the expression of spinal Cx43. Gap26, a specific Cx43 mimic peptide, attenuated not only morphine antinociceptive tolerance, but also the up‐regulation of spinal Cx43 expression, the activation of astrocytes, and N‐methyl‐D‐aspartic acid ( NMDA ) receptors ( NR 1 and NR 2B subunits), as well as the decreased GLT ‐1 expression induced by chronic morphine. MK ‐801, a noncompetitive NMDA receptors antagonist, suppressed the chronic morphine‐induced spinal Cx43 up‐regulation, astrocytes activation and decline of GLT ‐1 expression. Conclusions The spinal astrocytic Cx43 contributes to the development of morphine antinociceptive tolerance by activating astrocytes and NMDA receptors, and inhibiting GLT ‐1 expression. We also demonstrate that the role of interaction between the spinal astrocytic Cx43 and neuronal NMDA receptors is important in morphine tolerant rats." @default.
• W2101863176 created "2016-06-24" @default.
• W2101863176 creator A5014038945 @default.
• W2101863176 creator A5014355606 @default.
• W2101863176 creator A5019587287 @default.
• W2101863176 creator A5022600045 @default.
• W2101863176 creator A5027685680 @default.
• W2101863176 creator A5046087783 @default.
• W2101863176 date "2014-03-15" @default.
• W2101863176 modified "2023-10-18" @default.
• W2101863176 title "A Novel Role of Spinal Astrocytic Connexin 43: Mediating Morphine Antinociceptive Tolerance by Activation of NMDA Receptors and Inhibition of Glutamate Transporter-1 in Rats" @default.
• W2101863176 cites W1540277158 @default.
• W2101863176 cites W1968577463 @default.
• W2101863176 cites W1969191149 @default.
• W2101863176 cites W1969686168 @default.
• W2101863176 cites W1972467982 @default.
• W2101863176 cites W1973249845 @default.
• W2101863176 cites W1976142920 @default.
• W2101863176 cites W1982454686 @default.
• W2101863176 cites W1987783006 @default.
• W2101863176 cites W1989488177 @default.
• W2101863176 cites W1997283068 @default.
• W2101863176 cites W1998091457 @default.
• W2101863176 cites W2002737496 @default.
• W2101863176 cites W2006050476 @default.
• W2101863176 cites W2007174401 @default.
• W2101863176 cites W2008544937 @default.
• W2101863176 cites W2010225748 @default.
• W2101863176 cites W2016936987 @default.
• W2101863176 cites W2019076816 @default.
• W2101863176 cites W2025245706 @default.
• W2101863176 cites W2026793904 @default.
• W2101863176 cites W2027905503 @default.
• W2101863176 cites W2029535311 @default.
• W2101863176 cites W2033525233 @default.
• W2101863176 cites W2036777729 @default.
• W2101863176 cites W2040661246 @default.
• W2101863176 cites W2055326452 @default.
• W2101863176 cites W2058589594 @default.
• W2101863176 cites W2060938551 @default.
• W2101863176 cites W2064197300 @default.
• W2101863176 cites W2070433471 @default.
• W2101863176 cites W2073675839 @default.
• W2101863176 cites W2074545913 @default.
• W2101863176 cites W2078800769 @default.
• W2101863176 cites W2084990806 @default.
• W2101863176 cites W2086204051 @default.
• W2101863176 cites W2092068173 @default.
• W2101863176 cites W2093177418 @default.
• W2101863176 cites W2096602531 @default.
• W2101863176 cites W2114008977 @default.
• W2101863176 cites W2123728367 @default.
• W2101863176 cites W2124355299 @default.
• W2101863176 cites W2126112217 @default.
• W2101863176 cites W2130823810 @default.
• W2101863176 cites W2141778251 @default.
• W2101863176 cites W2145209811 @default.
• W2101863176 cites W2151305004 @default.
• W2101863176 cites W2153164502 @default.
• W2101863176 cites W2168631647 @default.
• W2101863176 cites W224499986 @default.
• W2101863176 cites W2334403376 @default.
• W2101863176 doi "https://doi.org/10.1111/cns.12244" @default.
• W2101863176 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6493140" @default.
• W2101863176 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24629168" @default.
• W2101863176 hasPublicationYear "2014" @default.
• W2101863176 type Work @default.
• W2101863176 sameAs 2101863176 @default.
• W2101863176 citedByCount "29" @default.
• W2101863176 countsByYear W21018631762014 @default.
• W2101863176 countsByYear W21018631762015 @default.
• W2101863176 countsByYear W21018631762016 @default.
• W2101863176 countsByYear W21018631762017 @default.
• W2101863176 countsByYear W21018631762018 @default.
• W2101863176 countsByYear W21018631762019 @default.
• W2101863176 countsByYear W21018631762022 @default.
• W2101863176 countsByYear W21018631762023 @default.
• W2101863176 crossrefType "journal-article" @default.
• W2101863176 hasAuthorship W2101863176A5014038945 @default.
• W2101863176 hasAuthorship W2101863176A5014355606 @default.
• W2101863176 hasAuthorship W2101863176A5019587287 @default.
• W2101863176 hasAuthorship W2101863176A5022600045 @default.
• W2101863176 hasAuthorship W2101863176A5027685680 @default.
• W2101863176 hasAuthorship W2101863176A5046087783 @default.
• W2101863176 hasBestOaLocation W21018631762 @default.
• W2101863176 hasConcept C126322002 @default.
• W2101863176 hasConcept C134018914 @default.
• W2101863176 hasConcept C15490471 @default.
• W2101863176 hasConcept C170493617 @default.
• W2101863176 hasConcept C185592680 @default.
• W2101863176 hasConcept C2777107010 @default.
• W2101863176 hasConcept C2777389121 @default.
• W2101863176 hasConcept C2777542381 @default.
• W2101863176 hasConcept C2777836312 @default.
• W2101863176 hasConcept C529278444 @default.
• W2101863176 hasConcept C61174792 @default.
• W2101863176 hasConcept C67018056 @default.
• W2101863176 hasConcept C71924100 @default.

• next