FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2101892626> ?p ?o ?g. }

• W2101892626 endingPage "H2831" @default.
• W2101892626 startingPage "H2824" @default.
• W2101892626 abstract "An inflammatory response followed by vascular injury plays an important role in neointima formation and development of atherosclerotic lesions, which are in part mediated by proinflammatory cytokines. Using a cuff injury model, we examined the effects of adenovirus-mediated overexpression of phosphatase and tensin homology deleted on chromosome 10 (PTEN) on neointima formation and the proinflammatory response. A cuff was placed around the femoral artery, and adenovirus expressing human PTEN type 1 (AdPTEN) or Escherichia coli β-galactosidase (AdLacZ) was injected between the cuff and the adventitia. After 14 days, the arteries were examined histopathologically and by Western blotting. The significant reduction of neointima formation by AdPTEN compared with AdLacZ was accompanied by reduced cell proliferation and increased adventitial cell apoptosis. AdPTEN also reduced expression of phosphorylated IκB-α, but not nonphosphorylated IκB-α. Western blotting revealed that AdPTEN reduced the cuff injury-induced expression levels of monocyte chemoattractant protein-1, TNF-α, and IL-1β and their expression in all layers of the arterial wall. In contrast, cuff-induced macrophage invasion, which was also inhibited by AdPTEN, was detected only at the intimal surface and in the adventitia. In cultured vascular smooth muscle cells, PTEN directly inhibited ANG II-induced monocyte chemoattractant protein-1 expression as quantified by real-time PCR and Western blotting. Our results suggest that overexpression of PTEN reduces neointima formation, possibly in part through inhibition of the inflammatory response by macrophage invasion and proinflammatory cytokine expression." @default.
• W2101892626 created "2016-06-24" @default.
• W2101892626 creator A5000613049 @default.
• W2101892626 creator A5009385244 @default.
• W2101892626 creator A5009727944 @default.
• W2101892626 creator A5034612427 @default.
• W2101892626 creator A5035832835 @default.
• W2101892626 creator A5037769750 @default.
• W2101892626 creator A5049348615 @default.
• W2101892626 creator A5069900354 @default.
• W2101892626 creator A5072960074 @default.
• W2101892626 creator A5089502824 @default.
• W2101892626 creator A5090558188 @default.
• W2101892626 date "2007-06-01" @default.
• W2101892626 modified "2023-09-30" @default.
• W2101892626 title "PTEN reduces cuff-induced neointima formation and proinflammatory cytokines" @default.
• W2101892626 cites W1971881044 @default.
• W2101892626 cites W1979973024 @default.
• W2101892626 cites W1983755918 @default.
• W2101892626 cites W1988102915 @default.
• W2101892626 cites W1988259001 @default.
• W2101892626 cites W2007192646 @default.
• W2101892626 cites W2016691951 @default.
• W2101892626 cites W2021117077 @default.
• W2101892626 cites W2025553759 @default.
• W2101892626 cites W2033199439 @default.
• W2101892626 cites W2042731815 @default.
• W2101892626 cites W2047277639 @default.
• W2101892626 cites W2047373489 @default.
• W2101892626 cites W2047779689 @default.
• W2101892626 cites W2048220093 @default.
• W2101892626 cites W2051020732 @default.
• W2101892626 cites W2064711537 @default.
• W2101892626 cites W2068427129 @default.
• W2101892626 cites W2075231392 @default.
• W2101892626 cites W2076457965 @default.
• W2101892626 cites W2091150202 @default.
• W2101892626 cites W2091959763 @default.
• W2101892626 cites W2113902557 @default.
• W2101892626 cites W2114025558 @default.
• W2101892626 cites W2117540279 @default.
• W2101892626 cites W2119869567 @default.
• W2101892626 cites W2124242147 @default.
• W2101892626 cites W2127963975 @default.
• W2101892626 cites W2135637900 @default.
• W2101892626 cites W2149057507 @default.
• W2101892626 cites W2150418339 @default.
• W2101892626 cites W2161810908 @default.
• W2101892626 cites W2271599549 @default.
• W2101892626 cites W2323216395 @default.
• W2101892626 doi "https://doi.org/10.1152/ajpheart.01221.2006" @default.
• W2101892626 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17277022" @default.
• W2101892626 hasPublicationYear "2007" @default.
• W2101892626 type Work @default.
• W2101892626 sameAs 2101892626 @default.
• W2101892626 citedByCount "35" @default.
• W2101892626 countsByYear W21018926262012 @default.
• W2101892626 countsByYear W21018926262013 @default.
• W2101892626 countsByYear W21018926262014 @default.
• W2101892626 countsByYear W21018926262015 @default.
• W2101892626 countsByYear W21018926262016 @default.
• W2101892626 countsByYear W21018926262018 @default.
• W2101892626 countsByYear W21018926262019 @default.
• W2101892626 countsByYear W21018926262021 @default.
• W2101892626 countsByYear W21018926262023 @default.
• W2101892626 crossrefType "journal-article" @default.
• W2101892626 hasAuthorship W2101892626A5000613049 @default.
• W2101892626 hasAuthorship W2101892626A5009385244 @default.
• W2101892626 hasAuthorship W2101892626A5009727944 @default.
• W2101892626 hasAuthorship W2101892626A5034612427 @default.
• W2101892626 hasAuthorship W2101892626A5035832835 @default.
• W2101892626 hasAuthorship W2101892626A5037769750 @default.
• W2101892626 hasAuthorship W2101892626A5049348615 @default.
• W2101892626 hasAuthorship W2101892626A5069900354 @default.
• W2101892626 hasAuthorship W2101892626A5072960074 @default.
• W2101892626 hasAuthorship W2101892626A5089502824 @default.
• W2101892626 hasAuthorship W2101892626A5090558188 @default.
• W2101892626 hasConcept C104317684 @default.
• W2101892626 hasConcept C126322002 @default.
• W2101892626 hasConcept C142724271 @default.
• W2101892626 hasConcept C164027704 @default.
• W2101892626 hasConcept C185592680 @default.
• W2101892626 hasConcept C203014093 @default.
• W2101892626 hasConcept C2776716733 @default.
• W2101892626 hasConcept C2776914184 @default.
• W2101892626 hasConcept C2777339539 @default.
• W2101892626 hasConcept C2777609662 @default.
• W2101892626 hasConcept C2778283817 @default.
• W2101892626 hasConcept C2778583881 @default.
• W2101892626 hasConcept C2779549131 @default.
• W2101892626 hasConcept C502942594 @default.
• W2101892626 hasConcept C55493867 @default.
• W2101892626 hasConcept C62478195 @default.
• W2101892626 hasConcept C71924100 @default.
• W2101892626 hasConcept C85265743 @default.
• W2101892626 hasConcept C86554907 @default.
• W2101892626 hasConcept C86803240 @default.
• W2101892626 hasConcept C95444343 @default.

• next