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- W2101892650 abstract "Dr Youssef and his colleagues (Clin Microbiol Infect 4: 70-74) were kind enough to note the contribution of my colleague Dr Brian Wharton and myself when we were working in Uganda ‘long ago' on infection in severely malnourished children [1.Phillips I Wharton B Acute bacterial infection in kwashiorkor and marasmus.Br Med J. 1968; 1: 407-409Crossref PubMed Scopus (52) Google Scholar]. In fact, recognition of the association is much older - we quoted Hesiod (c. 700 BC), but McCance, who was at the time of our report working in Uganda too, reviewed the history more fully [2.McCance RA The history significance and artiology of hunger oedema.Spec Rep Ser Med Res Counc (Lond). 1951; 275: 21-82PubMed Google Scholar]. It is noteworthy that even in our children with kwashiorkor or marasmus, translocation without localized infection seemed rarely responsible for bacteremia in our admittedly small series. Among seven children, nine episodes of bacteremia were caused in seven instances by Salmonella garoli (5) or S. typhimurium (2), almost always also in the gut and associated with diarrhea (in any case common in these children), and only in two instances by a ‘non-hemolytic streptococcus' or a klebsiella. We felt that these findings argued against the non-specific immunologic defect proposed by others, at least in most of our cases. It is interesting that the pathogenesis is still obscure. Incidentally, in our study of almost thirty years ago, the S. garoli isolates were all resistant to chloramphenicol, ampicillin, streptomycin and tetracycline. Plus Ca change …" @default.
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- W2101892650 date "1998-03-01" @default.
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- W2101892650 title "Malnutrition and infection" @default.
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- W2101892650 doi "https://doi.org/10.1111/j.1469-0691.1998.tb00387.x" @default.
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