FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2101909393> ?p ?o ?g. }

• W2101909393 endingPage "553" @default.
• W2101909393 startingPage "539" @default.
• W2101909393 abstract "Efficient phagocytosis of apoptotic cells is crucial for many cellular processes. One of earliest signals to the phagocyte is the expression of phosphatidylserine (PS) on the outer surface of the apoptotic cell that provides a potent `eat-me' signal. Recognition of PS occurs either directly, via PS receptor (PS-R), or indirectly via αvβ5(3) integrin or Mer-family tyrosine kinases through the opsonizing proteins milk fat globule-EGF factor 8 protein (MFG-E8), or growth arrest specific factor-6 (Gas6), respectively. Because Mer and αvβ5 integrin share PS-dependent recognition signals, we investigated their post-receptor signaling cascades following receptor activation. Using a constitutively active form for Mer (CDMer) or Gas6 as a ligand to stimulate Mer, we found that Mer activation induced a post-receptor signaling cascade involving Src-mediated tyrosine phosphorylation of FAK on Tyr861, the recruitment of FAKTyr861 to the αvβ5 integrin, and increased formation of p130CAS/CrkII/Dock180 complex to activate Rac1. Coexpression of Mer with αvβ5 integrin had a synergistic effect on Rac1 activation, lamellipodial formation and the phagocytosis of apoptotic cells. Interestingly, Gas6 or CDMer failed to stimulate p130CAS tyrosine phosphorylation or phagocytosis in β5-deficient CS-1 cells or in mutant β5ΔC-expressing cells, suggesting that Mer is directionally and functionally linked to the integrin pathway. The present data indicate that receptors that recognize apoptotic cells in the context of PS functionally crosstalk to amplify intracellular signals to internalize apoptotic cells. Moreover, our data link another PS-dependent signal to the CrkII/Dock180/Rac1 module." @default.
• W2101909393 created "2016-06-24" @default.
• W2101909393 creator A5029471583 @default.
• W2101909393 creator A5063809151 @default.
• W2101909393 creator A5083831569 @default.
• W2101909393 creator A5085508840 @default.
• W2101909393 date "2005-02-01" @default.
• W2101909393 modified "2023-10-17" @default.
• W2101909393 title "A role for Mer tyrosine kinase in αvβ5 integrin-mediated phagocytosis of apoptotic cells" @default.
• W2101909393 cites W1531051436 @default.
• W2101909393 cites W1532590486 @default.
• W2101909393 cites W1606012461 @default.
• W2101909393 cites W1646925026 @default.
• W2101909393 cites W1900495018 @default.
• W2101909393 cites W1913527145 @default.
• W2101909393 cites W1959486232 @default.
• W2101909393 cites W1965909442 @default.
• W2101909393 cites W1968521853 @default.
• W2101909393 cites W1971446783 @default.
• W2101909393 cites W1976214697 @default.
• W2101909393 cites W1982431975 @default.
• W2101909393 cites W1987241587 @default.
• W2101909393 cites W1991011809 @default.
• W2101909393 cites W1995728044 @default.
• W2101909393 cites W1998143581 @default.
• W2101909393 cites W2002694377 @default.
• W2101909393 cites W2002751390 @default.
• W2101909393 cites W2004786810 @default.
• W2101909393 cites W2011617127 @default.
• W2101909393 cites W2012078712 @default.
• W2101909393 cites W2022417898 @default.
• W2101909393 cites W2029315212 @default.
• W2101909393 cites W2036571449 @default.
• W2101909393 cites W2047013487 @default.
• W2101909393 cites W2048485183 @default.
• W2101909393 cites W2058493730 @default.
• W2101909393 cites W2058843732 @default.
• W2101909393 cites W2059930172 @default.
• W2101909393 cites W2060783475 @default.
• W2101909393 cites W2062620004 @default.
• W2101909393 cites W2070089465 @default.
• W2101909393 cites W2071481601 @default.
• W2101909393 cites W2073584744 @default.
• W2101909393 cites W2081607618 @default.
• W2101909393 cites W2082918908 @default.
• W2101909393 cites W2085560654 @default.
• W2101909393 cites W2091493364 @default.
• W2101909393 cites W2094173028 @default.
• W2101909393 cites W2099536948 @default.
• W2101909393 cites W2104373491 @default.
• W2101909393 cites W2110770741 @default.
• W2101909393 cites W2111306357 @default.
• W2101909393 cites W2118060829 @default.
• W2101909393 cites W2126712915 @default.
• W2101909393 cites W2128970579 @default.
• W2101909393 cites W2131523916 @default.
• W2101909393 cites W2134642517 @default.
• W2101909393 cites W2134961193 @default.
• W2101909393 cites W2135112491 @default.
• W2101909393 cites W2138127366 @default.
• W2101909393 cites W2149102487 @default.
• W2101909393 cites W2153312133 @default.
• W2101909393 cites W2153390050 @default.
• W2101909393 cites W2156621276 @default.
• W2101909393 cites W2186532357 @default.
• W2101909393 cites W2188472662 @default.
• W2101909393 cites W2227187219 @default.
• W2101909393 cites W2312810378 @default.
• W2101909393 cites W2315663906 @default.
• W2101909393 cites W4246506291 @default.
• W2101909393 doi "https://doi.org/10.1242/jcs.01632" @default.
• W2101909393 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15673687" @default.
• W2101909393 hasPublicationYear "2005" @default.
• W2101909393 type Work @default.
• W2101909393 sameAs 2101909393 @default.
• W2101909393 citedByCount "234" @default.
• W2101909393 countsByYear W21019093932012 @default.
• W2101909393 countsByYear W21019093932013 @default.
• W2101909393 countsByYear W21019093932014 @default.
• W2101909393 countsByYear W21019093932015 @default.
• W2101909393 countsByYear W21019093932016 @default.
• W2101909393 countsByYear W21019093932017 @default.
• W2101909393 countsByYear W21019093932018 @default.
• W2101909393 countsByYear W21019093932019 @default.
• W2101909393 countsByYear W21019093932020 @default.
• W2101909393 countsByYear W21019093932021 @default.
• W2101909393 countsByYear W21019093932022 @default.
• W2101909393 countsByYear W21019093932023 @default.
• W2101909393 crossrefType "journal-article" @default.
• W2101909393 hasAuthorship W2101909393A5029471583 @default.
• W2101909393 hasAuthorship W2101909393A5063809151 @default.
• W2101909393 hasAuthorship W2101909393A5083831569 @default.
• W2101909393 hasAuthorship W2101909393A5085508840 @default.
• W2101909393 hasBestOaLocation W21019093931 @default.
• W2101909393 hasConcept C101544691 @default.
• W2101909393 hasConcept C11960822 @default.
• W2101909393 hasConcept C160448771 @default.
• W2101909393 hasConcept C170493617 @default.

• next