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- W2101949269 abstract "Action potentials, the regenerative electrical waves traveling along axons, are the electrical trigger of synaptic neurotransmitter release. Aside from propagation failures at branch points, axon geometry is presumed to be immaterial to action potential propagation. Our numerical simulations, in contrast, indicate that in-line varicosities can significantly modulate action potentials, and over large distances. A single in-line varicosity can severely depress action potential amplitudes upstream from it while, within the varicosity, depolarization is amplified. Amplification within varicosities varies in a non-trivial manner with varicosity size, and is most pronounced for varicosities close in dimensions to Herring bodies, the secretory specializations of neurohypophysial axons. Enhancement in secretory terminals is equally significant. Amplification is dominated by geometrical factors, but does vary with the kinetics of voltage-gated ion channels." @default.
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- W2101949269 date "2009-02-01" @default.
- W2101949269 modified "2023-09-28" @default.
- W2101949269 title "Morphological Amplification of Action Potentials in Axonal Varicosities" @default.
- W2101949269 doi "https://doi.org/10.1016/j.bpj.2008.12.2471" @default.
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