Matches in SemOpenAlex for { <https://semopenalex.org/work/W2101953406> ?p ?o ?g. }
- W2101953406 abstract "Abstract Background Proteins are involved in many interactions with other proteins leading to networks that regulate and control a wide variety of physiological processes. Some of these proteins, called hub proteins or hubs, bind to many different protein partners. Protein intrinsic disorder, via diversity arising from structural plasticity or flexibility, provide a means for hubs to associate with many partners (Dunker AK, Cortese MS, Romero P, Iakoucheva LM, Uversky VN: Flexible Nets: The roles of intrinsic disorder in protein interaction networks. FEBS J 2005, 272:5129-5148). Results Here we present a detailed examination of two divergent examples: 1) p53, which uses different disordered regions to bind to different partners and which also has several individual disordered regions that each bind to multiple partners, and 2) 14-3-3, which is a structured protein that associates with many different intrinsically disordered partners. For both examples, three-dimensional structures of multiple complexes reveal that the flexibility and plasticity of intrinsically disordered protein regions as well as induced-fit changes in the structured regions are both important for binding diversity. Conclusions These data support the conjecture that hub proteins often utilize intrinsic disorder to bind to multiple partners and provide detailed information about induced fit in structured regions." @default.
- W2101953406 created "2016-06-24" @default.
- W2101953406 creator A5008253090 @default.
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- W2101953406 creator A5083199032 @default.
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- W2101953406 creator A5091785779 @default.
- W2101953406 date "2008-03-01" @default.
- W2101953406 modified "2023-10-18" @default.
- W2101953406 title "Flexible nets: disorder and induced fit in the associations of p53 and 14-3-3 with their partners" @default.
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