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• W2101979427 endingPage "1016" @default.
• W2101979427 startingPage "1009" @default.
• W2101979427 abstract "Some patients infected with human immunodeficiency virus (HIV) who are experiencing antiretroviral treatment failure have persistent improvement in CD4+ T cell counts despite high plasma viremia. To explore the mechanisms responsible for this phenomenon, 2 parameters influencing the dynamics of CD4+ T cells were evaluated: death of mature CD4+ T cells and replenishment of the CD4+ T cell pool by the thymus. The improvement in CD4+ T cells observed in patients with treatment failure was not correlated with spontaneous, Fas ligand-induced, or activation-induced T cell death. In contrast, a significant correlation between the improvement in CD4+ T cell counts and thymic output, as assessed by measurement of T cell receptor excision circles, was observed. These observations suggest that increased thymic output contributes to the dissociation between CD4+ T cell counts and viremia in patients failing antiretroviral therapy and support a model in which drug-resistant HIV strains may have reduced replication rates and pathogenicity in the thymus." @default.
• W2101979427 created "2016-06-24" @default.
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• W2101979427 date "2001-04-01" @default.
• W2101979427 modified "2023-10-10" @default.
• W2101979427 title "Discordant Increases in CD4⁺T Cells in Human Immunodeficiency Virus–Infected Patients Experiencing Virologic Treatment Failure: Role of Changes in Thymic Output and T Cell Death" @default.
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• W2101979427 doi "https://doi.org/10.1086/319285" @default.
• W2101979427 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11237824" @default.
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