Matches in SemOpenAlex for { <https://semopenalex.org/work/W2101996848> ?p ?o ?g. }
- W2101996848 endingPage "2348" @default.
- W2101996848 startingPage "2337" @default.
- W2101996848 abstract "In order to study the function of human cytomegalovirus (HCMV) immediate early gene 2 (ie2) (UL122) gene products made at late times during infection, cDNA clones were isolated from an expression library made with 74 h post-infection mRNA. Based on screening of the library, 1 % of transcripts in infected cells at this time were ie2 region-specific, and transcripts encoding γIE2338aa, a 40K late gene product, were more abundant than those encoding IE2 579aa, an a gene product made throughout infection. As expected, the cDNA capable of directing the expression of γIE2338aa was derived from a contiguous genomic region within exon 5 of the ie1/ie2 region. The cDNA clones encoding γIE2338aa and IE2579aa were compared for their ability to trans-activate viral and cellular promoters and to repress expression from the ie1/ie2 promoter via the ie2 cis-repression signal. Unexpectedly, γIE2338aa trans-activated a variety of test promoters when cotransfected with the major a gene product, IE1491aa. Promoters derived from the cellular β-actin gene, the simian virus 40 early region and the human immunodeficiency virus were all responsive to γIE2338aa plus IE1491aa, although several β promoters derived from the HCMV genome were unresponsive. Thus, this abundant late product from the ie2 region may play a role in trans-activation in addition to its role as a repressor of α gene expression." @default.
- W2101996848 created "2016-06-24" @default.
- W2101996848 creator A5031203614 @default.
- W2101996848 creator A5035976818 @default.
- W2101996848 creator A5076472842 @default.
- W2101996848 date "1994-09-01" @default.
- W2101996848 modified "2023-10-18" @default.
- W2101996848 title "Human cytomegalovirus late protein encoded by ie2: a trans-activator as well as a repressor of gene expression" @default.
- W2101996848 cites W142428048 @default.
- W2101996848 cites W1479710813 @default.
- W2101996848 cites W1492794412 @default.
- W2101996848 cites W1496664311 @default.
- W2101996848 cites W1501688137 @default.
- W2101996848 cites W1533341668 @default.
- W2101996848 cites W1534284325 @default.
- W2101996848 cites W1551369539 @default.
- W2101996848 cites W1565293712 @default.
- W2101996848 cites W1572335427 @default.
- W2101996848 cites W1582479873 @default.
- W2101996848 cites W1586482908 @default.
- W2101996848 cites W1592287063 @default.
- W2101996848 cites W1608297032 @default.
- W2101996848 cites W1608665731 @default.
- W2101996848 cites W1671485497 @default.
- W2101996848 cites W174223971 @default.
- W2101996848 cites W1763782658 @default.
- W2101996848 cites W1766643663 @default.
- W2101996848 cites W1780379435 @default.
- W2101996848 cites W1780875019 @default.
- W2101996848 cites W1797852794 @default.
- W2101996848 cites W1870943906 @default.
- W2101996848 cites W1933815796 @default.
- W2101996848 cites W1938389724 @default.
- W2101996848 cites W1947794291 @default.
- W2101996848 cites W1949490448 @default.
- W2101996848 cites W1952117209 @default.
- W2101996848 cites W1957956386 @default.
- W2101996848 cites W1958288590 @default.
- W2101996848 cites W1960156471 @default.
- W2101996848 cites W1970697372 @default.
- W2101996848 cites W1984706880 @default.
- W2101996848 cites W1986510350 @default.
- W2101996848 cites W1991548997 @default.
- W2101996848 cites W1994456766 @default.
- W2101996848 cites W1997320176 @default.
- W2101996848 cites W1999899106 @default.
- W2101996848 cites W2002397702 @default.
- W2101996848 cites W2019332162 @default.
- W2101996848 cites W2038804719 @default.
- W2101996848 cites W2043649633 @default.
- W2101996848 cites W2043663228 @default.
- W2101996848 cites W2045512807 @default.
- W2101996848 cites W2076613886 @default.
- W2101996848 cites W2089559330 @default.
- W2101996848 cites W2112358326 @default.
- W2101996848 cites W2114882367 @default.
- W2101996848 cites W2116917349 @default.
- W2101996848 cites W2130462159 @default.
- W2101996848 cites W2133413615 @default.
- W2101996848 cites W2134764060 @default.
- W2101996848 cites W2144206181 @default.
- W2101996848 cites W2145768518 @default.
- W2101996848 cites W2151277481 @default.
- W2101996848 cites W2155086697 @default.
- W2101996848 cites W2161867184 @default.
- W2101996848 cites W316635155 @default.
- W2101996848 cites W2400699246 @default.
- W2101996848 doi "https://doi.org/10.1099/0022-1317-75-9-2337" @default.
- W2101996848 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8077932" @default.
- W2101996848 hasPublicationYear "1994" @default.
- W2101996848 type Work @default.
- W2101996848 sameAs 2101996848 @default.
- W2101996848 citedByCount "42" @default.
- W2101996848 countsByYear W21019968482015 @default.
- W2101996848 countsByYear W21019968482018 @default.
- W2101996848 countsByYear W21019968482020 @default.
- W2101996848 countsByYear W21019968482021 @default.
- W2101996848 crossrefType "journal-article" @default.
- W2101996848 hasAuthorship W2101996848A5031203614 @default.
- W2101996848 hasAuthorship W2101996848A5035976818 @default.
- W2101996848 hasAuthorship W2101996848A5076472842 @default.
- W2101996848 hasBestOaLocation W21019968481 @default.
- W2101996848 hasConcept C101762097 @default.
- W2101996848 hasConcept C104317684 @default.
- W2101996848 hasConcept C150194340 @default.
- W2101996848 hasConcept C153911025 @default.
- W2101996848 hasConcept C158448853 @default.
- W2101996848 hasConcept C159047783 @default.
- W2101996848 hasConcept C165864922 @default.
- W2101996848 hasConcept C187882448 @default.
- W2101996848 hasConcept C195286587 @default.
- W2101996848 hasConcept C2779820661 @default.
- W2101996848 hasConcept C36823959 @default.
- W2101996848 hasConcept C54355233 @default.
- W2101996848 hasConcept C62944979 @default.
- W2101996848 hasConcept C86803240 @default.
- W2101996848 hasConcept C88045685 @default.
- W2101996848 hasConceptScore W2101996848C101762097 @default.