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- W2101996917 abstract "Recessive lethal mutations in the fat locus of Drosophila cause hyperplastic, tumor-like overgrowth of larval imaginal discs, defects in differentiation and morphogenesis, and death during the pupal stage. Clones of mutant cells induced by mitotic recombination demonstrate that the overgrowth phenotype is cell autonomous. Here we show that the fat locus encodes a novel member of the cadherin gene superfamily: an enormous transmembrane protein of over 5000 amino acids with a putative signal sequence, 34 tandem cadherin domains, four EGF-like repeats, a transmembrane domain, and a novel cytoplasmic domain. Two recessive lethal alleles contain alterations in the fat coding sequence, and the dominant fat allele, Gull, contains an insertion of a transposable element in the 33rd cadherin domain. Thus, this novel member of the cadherin gene superfamily functions as a tumor suppressor gene and is required for correct morphogenesis." @default.
- W2101996917 created "2016-06-24" @default.
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- W2101996917 date "1991-11-01" @default.
- W2101996917 modified "2023-10-16" @default.
- W2101996917 title "The fat tumor suppressor gene in Drosophila encodes a novel member of the cadherin gene superfamily" @default.
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- W2101996917 cites W1577992745 @default.
- W2101996917 cites W158610362 @default.
- W2101996917 cites W1835871649 @default.
- W2101996917 cites W1882780242 @default.
- W2101996917 cites W1966087185 @default.
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- W2101996917 doi "https://doi.org/10.1016/0092-8674(91)90359-7" @default.
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- W2101996917 hasPublicationYear "1991" @default.
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