FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2102005071> ?p ?o ?g. }

• W2102005071 endingPage "655" @default.
• W2102005071 startingPage "649" @default.
• W2102005071 abstract "<b>Objectives:</b> To study the expression of cysteine proteinases, particularly cathepsin K, and their extracellular inhibitor cystatin C in articular cartilage of transgenic Del1 mice which harbour a short deletion mutation in a type II collagen transgene and are predisposed to early onset osteoarthritis. <b>Methods:</b> Northern analysis was used to measure mRNA levels of cathepsins B, H, K, L, and S, and cystatin C in total RNA extracted from knee joints of Del1 mice, using their non-transgenic litter mates as controls. Immunohistochemistry and morphometry was used to study the distribution of cathepsin K and cystatin C in the knee joints. <b>Results:</b> Up regulation of cathepsin K mRNA expression was seen in the knee joints of transgenic Del1 mice at the onset of cartilage degeneration. Cathepsin K was found near sites of matrix destruction in articular chondrocytes, particularly in clusters of proliferating cells, and in calcified cartilaginous matrix. In intact articular cartilage of control animals, cathepsin K was only seen in a small number of chondrocytes. Upon aging, control animals also developed osteoarthritis, which was accompanied by increased cathepsin K expression. Cystatin C was mostly localised in and around chondrocytes located in calcified cartilage, with no obvious association with the onset of cartilage degeneration. <b>Conclusion:</b> The temporospatial distribution of cathepsin K in osteoarthritic cartilage suggests a role for this enzyme in the pathogenesis of osteoarthritis. Because cathepsin K can digest cartilage matrix components it may contribute to the development of osteoarthritic lesions. These data may provide new clues for the development of treatments aimed at preventing cartilage degeneration." @default.
• W2102005071 created "2016-06-24" @default.
• W2102005071 creator A5025584854 @default.
• W2102005071 creator A5036938343 @default.
• W2102005071 creator A5052103597 @default.
• W2102005071 creator A5071566399 @default.
• W2102005071 creator A5080592958 @default.
• W2102005071 date "2004-03-17" @default.
• W2102005071 modified "2023-10-13" @default.
• W2102005071 title "Up regulation of cathepsin K expression in articular chondrocytes in a transgenic mouse model for osteoarthritis" @default.
• W2102005071 cites W123379006 @default.
• W2102005071 cites W1712774648 @default.
• W2102005071 cites W1762318613 @default.
• W2102005071 cites W1842433572 @default.
• W2102005071 cites W1866549457 @default.
• W2102005071 cites W1964322050 @default.
• W2102005071 cites W1973669832 @default.
• W2102005071 cites W1984079474 @default.
• W2102005071 cites W1986768873 @default.
• W2102005071 cites W1987778582 @default.
• W2102005071 cites W1989960578 @default.
• W2102005071 cites W1991947705 @default.
• W2102005071 cites W2000095920 @default.
• W2102005071 cites W2001270166 @default.
• W2102005071 cites W2010266021 @default.
• W2102005071 cites W2010846007 @default.
• W2102005071 cites W2013351805 @default.
• W2102005071 cites W2016749697 @default.
• W2102005071 cites W2022619943 @default.
• W2102005071 cites W2023548097 @default.
• W2102005071 cites W2029347297 @default.
• W2102005071 cites W2040385059 @default.
• W2102005071 cites W2045503348 @default.
• W2102005071 cites W2058721833 @default.
• W2102005071 cites W2060333964 @default.
• W2102005071 cites W2062082248 @default.
• W2102005071 cites W2063035603 @default.
• W2102005071 cites W2067439258 @default.
• W2102005071 cites W2070094372 @default.
• W2102005071 cites W2074860567 @default.
• W2102005071 cites W2076747902 @default.
• W2102005071 cites W2076942388 @default.
• W2102005071 cites W2078383562 @default.
• W2102005071 cites W2093531586 @default.
• W2102005071 cites W2094379754 @default.
• W2102005071 cites W2095512005 @default.
• W2102005071 cites W2099284644 @default.
• W2102005071 cites W2108490599 @default.
• W2102005071 cites W2112069529 @default.
• W2102005071 cites W2122942847 @default.
• W2102005071 cites W2168376480 @default.
• W2102005071 cites W2281587014 @default.
• W2102005071 cites W2332433073 @default.
• W2102005071 cites W2407847373 @default.
• W2102005071 cites W2418981970 @default.
• W2102005071 cites W2468125393 @default.
• W2102005071 cites W4234856613 @default.
• W2102005071 doi "https://doi.org/10.1136/ard.2002.004671" @default.
• W2102005071 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1755014" @default.
• W2102005071 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15140771" @default.
• W2102005071 hasPublicationYear "2004" @default.
• W2102005071 type Work @default.
• W2102005071 sameAs 2102005071 @default.
• W2102005071 citedByCount "77" @default.
• W2102005071 countsByYear W21020050712012 @default.
• W2102005071 countsByYear W21020050712013 @default.
• W2102005071 countsByYear W21020050712014 @default.
• W2102005071 countsByYear W21020050712015 @default.
• W2102005071 countsByYear W21020050712016 @default.
• W2102005071 countsByYear W21020050712017 @default.
• W2102005071 countsByYear W21020050712018 @default.
• W2102005071 countsByYear W21020050712019 @default.
• W2102005071 countsByYear W21020050712020 @default.
• W2102005071 countsByYear W21020050712022 @default.
• W2102005071 countsByYear W21020050712023 @default.
• W2102005071 crossrefType "journal-article" @default.
• W2102005071 hasAuthorship W2102005071A5025584854 @default.
• W2102005071 hasAuthorship W2102005071A5036938343 @default.
• W2102005071 hasAuthorship W2102005071A5052103597 @default.
• W2102005071 hasAuthorship W2102005071A5071566399 @default.
• W2102005071 hasAuthorship W2102005071A5080592958 @default.
• W2102005071 hasBestOaLocation W21020050711 @default.
• W2102005071 hasConcept C101990758 @default.
• W2102005071 hasConcept C102230213 @default.
• W2102005071 hasConcept C104317684 @default.
• W2102005071 hasConcept C105702510 @default.
• W2102005071 hasConcept C126322002 @default.
• W2102005071 hasConcept C141035611 @default.
• W2102005071 hasConcept C142724271 @default.
• W2102005071 hasConcept C151701858 @default.
• W2102005071 hasConcept C167844969 @default.
• W2102005071 hasConcept C170493617 @default.
• W2102005071 hasConcept C181199279 @default.
• W2102005071 hasConcept C189165786 @default.
• W2102005071 hasConcept C204787440 @default.
• W2102005071 hasConcept C2776033226 @default.
• W2102005071 hasConcept C2776164576 @default.
• W2102005071 hasConcept C2780034444 @default.

• next