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• W2102014851 abstract "ABSTRACT Recently, the BM has been shown to play a key role in regulating the survival and function of memory T cells. However, the impact of aging on these processes has not yet been studied. We demonstrate that the number of CD4+ and CD8+ T cells in the BM is maintained during aging. However, the composition of the T cell pool in the aged BM is altered with a decline of naïve and an increase in TEM cells. In contrast to the PB, a highly activated CD8+CD28– T cell population, which lacks the late differentiation marker CD57, accumulates in the BM of elderly persons. IL-6 and IL-15, which are both increased in the aged BM, efficiently induce the activation, proliferation, and differentiation of CD8+ T cells in vitro, highlighting a role of these cytokines in the age-dependent accumulation of highly activated CD8+CD28– T cells in the BM. Yet, these age-related changes do not impair the maintenance of a high number of polyfunctional memory CD4+ and CD8+ T cells in the BM of elderly persons. In summary, aging leads to the accumulation of a highly activated CD8+CD28– T cell population in the BM, which is driven by the age-related increase of IL-6 and IL-15. Despite these changes, the aged BM is a rich source of polyfunctional memory T cells and may thus represent an important line of defense to fight recurrent infections in old age." @default.
• W2102014851 created "2016-06-24" @default.
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• W2102014851 date "2011-10-19" @default.
• W2102014851 modified "2023-10-03" @default.
• W2102014851 title "The impact of aging on memory T cell phenotype and function in the human bone marrow" @default.
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• W2102014851 doi "https://doi.org/10.1189/jlb.0611299" @default.
• W2102014851 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22013229" @default.
• W2102014851 hasPublicationYear "2011" @default.
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