Matches in SemOpenAlex for { <https://semopenalex.org/work/W2102020172> ?p ?o ?g. }
- W2102020172 endingPage "630" @default.
- W2102020172 startingPage "626" @default.
- W2102020172 abstract "Objectives To test the hypothesis that females presenting for coronary artery bypass graft (CABG) surgery are at a higher risk of left ventricular diastolic dysfunction (LVDD) and that age and gender interact to influence this risk. Design Retrospective observational study. Setting Tertiary university hospital. Participants Eight hundred-ninety-five adult patients undergoing CABG surgery. Interventions None. Measurements and Main Results Baseline diastolic function was graded according to a predefined Doppler-based algorithm, which defined LVDD as a binary variable (grades 2 and 3 only) and as a continuous variable (E/e’ ratio). The authors found that women were more likely to present with LVDD in 2 multivariate regression models using both LVDD definitions (odds ratio = 2.7; p<0.0001 for logistic model, and parameter estimate (PE) = 2.8; p<0.0001 for the linear model). In addition, there was a significant age and gender interaction on the risk of LVDD in the linear model (PE = 0.08; p = 0.01). A restricted cubic splines analysis revealed a progressively higher risk of LVDD (predicted E/e’ ratio) among older women. Conclusions The authors confirmed that women undergoing CABG surgery are at higher risk of LVDD compared to men with a significant age-gender interaction suggesting a possible age-related differential effect on LVDD between the genders, a phenomenon previously demonstrated in preclinical studies. Therapies aimed at amelioration of diastolic dysfunction additionally should consider the higher risk in females, especially within the older subset of the patient population. To test the hypothesis that females presenting for coronary artery bypass graft (CABG) surgery are at a higher risk of left ventricular diastolic dysfunction (LVDD) and that age and gender interact to influence this risk. Retrospective observational study. Tertiary university hospital. Eight hundred-ninety-five adult patients undergoing CABG surgery. None. Baseline diastolic function was graded according to a predefined Doppler-based algorithm, which defined LVDD as a binary variable (grades 2 and 3 only) and as a continuous variable (E/e’ ratio). The authors found that women were more likely to present with LVDD in 2 multivariate regression models using both LVDD definitions (odds ratio = 2.7; p<0.0001 for logistic model, and parameter estimate (PE) = 2.8; p<0.0001 for the linear model). In addition, there was a significant age and gender interaction on the risk of LVDD in the linear model (PE = 0.08; p = 0.01). A restricted cubic splines analysis revealed a progressively higher risk of LVDD (predicted E/e’ ratio) among older women. The authors confirmed that women undergoing CABG surgery are at higher risk of LVDD compared to men with a significant age-gender interaction suggesting a possible age-related differential effect on LVDD between the genders, a phenomenon previously demonstrated in preclinical studies. Therapies aimed at amelioration of diastolic dysfunction additionally should consider the higher risk in females, especially within the older subset of the patient population." @default.
- W2102020172 created "2016-06-24" @default.
- W2102020172 creator A5022890058 @default.
- W2102020172 creator A5049250143 @default.
- W2102020172 creator A5058843042 @default.
- W2102020172 creator A5063843642 @default.
- W2102020172 creator A5068957802 @default.
- W2102020172 creator A5073629811 @default.
- W2102020172 date "2014-06-01" @default.
- W2102020172 modified "2023-09-25" @default.
- W2102020172 title "Diastolic Dysfunction in Patients Undergoing Cardiac Surgery: The Role of Gender and Age-Gender Interaction" @default.
- W2102020172 cites W1593442063 @default.
- W2102020172 cites W1966759687 @default.
- W2102020172 cites W1968600609 @default.
- W2102020172 cites W2033989169 @default.
- W2102020172 cites W2037362240 @default.
- W2102020172 cites W2050346587 @default.
- W2102020172 cites W2070742041 @default.
- W2102020172 cites W2086936134 @default.
- W2102020172 cites W2089923812 @default.
- W2102020172 cites W2098589322 @default.
- W2102020172 cites W2109281287 @default.
- W2102020172 cites W2109857015 @default.
- W2102020172 cites W2113105692 @default.
- W2102020172 cites W2127039247 @default.
- W2102020172 cites W2136695771 @default.
- W2102020172 cites W2137784332 @default.
- W2102020172 cites W2138650758 @default.
- W2102020172 cites W2140334010 @default.
- W2102020172 cites W2144048294 @default.
- W2102020172 cites W2145723110 @default.
- W2102020172 cites W2147381349 @default.
- W2102020172 cites W2155559652 @default.
- W2102020172 cites W2156012869 @default.
- W2102020172 cites W2158571739 @default.
- W2102020172 cites W2159391743 @default.
- W2102020172 cites W2168870305 @default.
- W2102020172 cites W2169049493 @default.
- W2102020172 cites W2172227211 @default.
- W2102020172 cites W29349396 @default.
- W2102020172 cites W3022179669 @default.
- W2102020172 cites W80592372 @default.
- W2102020172 doi "https://doi.org/10.1053/j.jvca.2013.11.010" @default.
- W2102020172 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24675001" @default.
- W2102020172 hasPublicationYear "2014" @default.
- W2102020172 type Work @default.
- W2102020172 sameAs 2102020172 @default.
- W2102020172 citedByCount "8" @default.
- W2102020172 countsByYear W21020201722015 @default.
- W2102020172 countsByYear W21020201722016 @default.
- W2102020172 countsByYear W21020201722018 @default.
- W2102020172 countsByYear W21020201722021 @default.
- W2102020172 countsByYear W21020201722022 @default.
- W2102020172 crossrefType "journal-article" @default.
- W2102020172 hasAuthorship W2102020172A5022890058 @default.
- W2102020172 hasAuthorship W2102020172A5049250143 @default.
- W2102020172 hasAuthorship W2102020172A5058843042 @default.
- W2102020172 hasAuthorship W2102020172A5063843642 @default.
- W2102020172 hasAuthorship W2102020172A5068957802 @default.
- W2102020172 hasAuthorship W2102020172A5073629811 @default.
- W2102020172 hasConcept C126322002 @default.
- W2102020172 hasConcept C141071460 @default.
- W2102020172 hasConcept C151956035 @default.
- W2102020172 hasConcept C156957248 @default.
- W2102020172 hasConcept C164705383 @default.
- W2102020172 hasConcept C167135981 @default.
- W2102020172 hasConcept C23131810 @default.
- W2102020172 hasConcept C2775901492 @default.
- W2102020172 hasConcept C2776820930 @default.
- W2102020172 hasConcept C2778789114 @default.
- W2102020172 hasConcept C2908647359 @default.
- W2102020172 hasConcept C57900726 @default.
- W2102020172 hasConcept C71924100 @default.
- W2102020172 hasConcept C84393581 @default.
- W2102020172 hasConcept C99454951 @default.
- W2102020172 hasConceptScore W2102020172C126322002 @default.
- W2102020172 hasConceptScore W2102020172C141071460 @default.
- W2102020172 hasConceptScore W2102020172C151956035 @default.
- W2102020172 hasConceptScore W2102020172C156957248 @default.
- W2102020172 hasConceptScore W2102020172C164705383 @default.
- W2102020172 hasConceptScore W2102020172C167135981 @default.
- W2102020172 hasConceptScore W2102020172C23131810 @default.
- W2102020172 hasConceptScore W2102020172C2775901492 @default.
- W2102020172 hasConceptScore W2102020172C2776820930 @default.
- W2102020172 hasConceptScore W2102020172C2778789114 @default.
- W2102020172 hasConceptScore W2102020172C2908647359 @default.
- W2102020172 hasConceptScore W2102020172C57900726 @default.
- W2102020172 hasConceptScore W2102020172C71924100 @default.
- W2102020172 hasConceptScore W2102020172C84393581 @default.
- W2102020172 hasConceptScore W2102020172C99454951 @default.
- W2102020172 hasIssue "3" @default.
- W2102020172 hasLocation W21020201721 @default.
- W2102020172 hasLocation W21020201722 @default.
- W2102020172 hasOpenAccess W2102020172 @default.
- W2102020172 hasPrimaryLocation W21020201721 @default.
- W2102020172 hasRelatedWork W1592296313 @default.
- W2102020172 hasRelatedWork W163707158 @default.
- W2102020172 hasRelatedWork W1992625669 @default.