Matches in SemOpenAlex for { <https://semopenalex.org/work/W2102026512> ?p ?o ?g. }
- W2102026512 abstract "Abstract Background Low-density lipoprotein (LDL) cholesterol lowering is a primary goal in clinical management of patients with cardiovascular disease, but traditional cholesterol levels may not accurately reflect the true atherogenicity of plasma lipid profiles. The size and concentration of lipoprotein particles, which transport cholesterol and triglycerides, may provide additional information for accurately assessing cardiovascular risk. This study evaluated changes in plasma lipoprotein profiles determined by nuclear magnetic resonance (NMR) spectroscopy in patients participating in a prospective, nonrandomized lifestyle modification program designed to reverse or stabilize progression of coronary artery disease (CAD) to improve our understanding of lipoprotein management in cardiac patients. Results The lifestyle intervention was effective in producing significant changes in lipoprotein subclasses that contribute to CAD risk. There was a clear beneficial effect on the total number of LDL particles (-8.3%, p < 0.05 compared to matched controls), small dense LDL particles (-9.5%, p < 0.05), and LDL particle size (+0.8%; p < 0.05). Likewise, participants showed significant improvement in traditional CAD risk factors such as body mass index (-9.9%, p < 0.01 compared to controls), total cholesterol (-5.5%, p < 0.05), physical fitness (+37.2%, p < 0.01), and future risk for CAD (-7.9%, p < 0.01). Men and women responded differently to the program for all clinically-relevant variables, with men deriving greater benefit in terms of lipoprotein atherogenicity. Plasma lipid and lipoprotein responses to the lifestyle change program were not confounded by lipid-lowering medications. Conclusion In at risk patients motivated to participate, an intensive lifestyle change program can effectively alter traditional CAD risk factors and plasma lipoprotein subclasses and may reduce risk for cardiovascular events. Improvements in lipoprotein subclasses are more evident in men compared to women." @default.
- W2102026512 created "2016-06-24" @default.
- W2102026512 creator A5006593727 @default.
- W2102026512 creator A5007009063 @default.
- W2102026512 creator A5014661710 @default.
- W2102026512 creator A5051474925 @default.
- W2102026512 creator A5059172090 @default.
- W2102026512 creator A5062548027 @default.
- W2102026512 creator A5062944300 @default.
- W2102026512 date "2009-06-29" @default.
- W2102026512 modified "2023-09-26" @default.
- W2102026512 title "Effects of cardiovascular lifestyle change on lipoprotein subclass profiles defined by nuclear magnetic resonance spectroscopy" @default.
- W2102026512 cites W1969463779 @default.
- W2102026512 cites W1970083516 @default.
- W2102026512 cites W1984875752 @default.
- W2102026512 cites W1990421153 @default.
- W2102026512 cites W1993707348 @default.
- W2102026512 cites W1996810831 @default.
- W2102026512 cites W2006688731 @default.
- W2102026512 cites W2008740070 @default.
- W2102026512 cites W2009468751 @default.
- W2102026512 cites W2009862253 @default.
- W2102026512 cites W2015169926 @default.
- W2102026512 cites W2017823171 @default.
- W2102026512 cites W2019665103 @default.
- W2102026512 cites W2019863077 @default.
- W2102026512 cites W2021360285 @default.
- W2102026512 cites W2025643440 @default.
- W2102026512 cites W2028872016 @default.
- W2102026512 cites W2045113865 @default.
- W2102026512 cites W2050758709 @default.
- W2102026512 cites W2052926891 @default.
- W2102026512 cites W2053802334 @default.
- W2102026512 cites W2054506834 @default.
- W2102026512 cites W2055409225 @default.
- W2102026512 cites W2056939999 @default.
- W2102026512 cites W2064303441 @default.
- W2102026512 cites W2090819588 @default.
- W2102026512 cites W2091879515 @default.
- W2102026512 cites W2092831846 @default.
- W2102026512 cites W2096190290 @default.
- W2102026512 cites W2108840705 @default.
- W2102026512 cites W2109595108 @default.
- W2102026512 cites W2109806543 @default.
- W2102026512 cites W2110448405 @default.
- W2102026512 cites W2112965137 @default.
- W2102026512 cites W2117205405 @default.
- W2102026512 cites W2124501164 @default.
- W2102026512 cites W2124931981 @default.
- W2102026512 cites W2129735711 @default.
- W2102026512 cites W2131215476 @default.
- W2102026512 cites W2131620609 @default.
- W2102026512 cites W2138673237 @default.
- W2102026512 cites W2139445156 @default.
- W2102026512 cites W2139887584 @default.
- W2102026512 cites W2145167597 @default.
- W2102026512 cites W2146262274 @default.
- W2102026512 cites W2151775414 @default.
- W2102026512 cites W2152086330 @default.
- W2102026512 cites W2155303176 @default.
- W2102026512 cites W2156255102 @default.
- W2102026512 cites W2160390128 @default.
- W2102026512 cites W2163839624 @default.
- W2102026512 cites W2164346577 @default.
- W2102026512 cites W2165947313 @default.
- W2102026512 cites W2166309615 @default.
- W2102026512 cites W2168623541 @default.
- W2102026512 cites W2170123185 @default.
- W2102026512 cites W35016999 @default.
- W2102026512 cites W38523360 @default.
- W2102026512 doi "https://doi.org/10.1186/1476-511x-8-26" @default.
- W2102026512 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2713234" @default.
- W2102026512 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19563671" @default.
- W2102026512 hasPublicationYear "2009" @default.
- W2102026512 type Work @default.
- W2102026512 sameAs 2102026512 @default.
- W2102026512 citedByCount "22" @default.
- W2102026512 countsByYear W21020265122012 @default.
- W2102026512 countsByYear W21020265122013 @default.
- W2102026512 countsByYear W21020265122014 @default.
- W2102026512 countsByYear W21020265122015 @default.
- W2102026512 countsByYear W21020265122016 @default.
- W2102026512 countsByYear W21020265122017 @default.
- W2102026512 countsByYear W21020265122020 @default.
- W2102026512 countsByYear W21020265122021 @default.
- W2102026512 countsByYear W21020265122022 @default.
- W2102026512 countsByYear W21020265122023 @default.
- W2102026512 crossrefType "journal-article" @default.
- W2102026512 hasAuthorship W2102026512A5006593727 @default.
- W2102026512 hasAuthorship W2102026512A5007009063 @default.
- W2102026512 hasAuthorship W2102026512A5014661710 @default.
- W2102026512 hasAuthorship W2102026512A5051474925 @default.
- W2102026512 hasAuthorship W2102026512A5059172090 @default.
- W2102026512 hasAuthorship W2102026512A5062548027 @default.
- W2102026512 hasAuthorship W2102026512A5062944300 @default.
- W2102026512 hasBestOaLocation W21020265121 @default.
- W2102026512 hasConcept C126322002 @default.
- W2102026512 hasConcept C134018914 @default.
- W2102026512 hasConcept C148257392 @default.
- W2102026512 hasConcept C159654299 @default.