Matches in SemOpenAlex for { <https://semopenalex.org/work/W2102030238> ?p ?o ?g. }
- W2102030238 endingPage "1500" @default.
- W2102030238 startingPage "1494" @default.
- W2102030238 abstract "<h3>BACKGROUND AND PURPOSE:</h3> Corticothalamic networks are considered core pathologic substrates for idiopathic generalized epilepsy; however, the predominant epileptogenic epicenters within these networks are still largely unknown. The current study aims to identify these epicenters by resting-state functional connectivity. <h3>MATERIALS AND METHODS:</h3> To identify epicenters within the corticothalamic networks in idiopathic generalized epilepsy, we retrospectively studied a large cohort of patients with this condition (<i>n</i> = 97) along with healthy controls (<i>n</i> = 123) by resting-state functional MR imaging. The thalamus was functionally divided into subregions corresponding to distinct cortical lobes for 5 parallel corticothalamic networks. The functional connectivity between each voxel in the cortical lobe and the corresponding thalamic subregion was calculated, and functional connectivity strength was used to evaluate the interconnectivity of voxels in the cortex and thalamus. <h3>RESULTS:</h3> The projection of 5 cortical lobes to the thalamus is consistent with previous histologic findings in humans. Compared with controls, patients with idiopathic generalized epilepsy showed increased functional connectivity strength in 4 corticothalamic networks: 1) the supplementary motor area, pulvinar, and ventral anterior nucleus in the prefrontal-thalamic network; 2) the premotor cortex and ventrolateral nucleus in motor/premotor-thalamic networks; 3) the visual cortex, posterior default mode regions, and pulvinar in parietal/occipital-thalamic networks; and 4) the middle temporal gyrus in the temporal-thalamic network. <h3>CONCLUSIONS:</h3> Several key nodes were distinguished in 4 corticothalamic networks. The identification of these epicenters refines the corticothalamic network theory and provides insight into the pathophysiology of idiopathic generalized epilepsy." @default.
- W2102030238 created "2016-06-24" @default.
- W2102030238 creator A5002716505 @default.
- W2102030238 creator A5009233581 @default.
- W2102030238 creator A5021628199 @default.
- W2102030238 creator A5024443914 @default.
- W2102030238 creator A5028785687 @default.
- W2102030238 creator A5045369725 @default.
- W2102030238 creator A5049470216 @default.
- W2102030238 creator A5063103450 @default.
- W2102030238 creator A5066130076 @default.
- W2102030238 creator A5070001088 @default.
- W2102030238 creator A5078434538 @default.
- W2102030238 creator A5082165277 @default.
- W2102030238 date "2015-04-23" @default.
- W2102030238 modified "2023-10-02" @default.
- W2102030238 title "Identifying Corticothalamic Network Epicenters in Patients with Idiopathic Generalized Epilepsy" @default.
- W2102030238 cites W1576221075 @default.
- W2102030238 cites W1634443637 @default.
- W2102030238 cites W1963781350 @default.
- W2102030238 cites W1969312384 @default.
- W2102030238 cites W1972694982 @default.
- W2102030238 cites W1980276616 @default.
- W2102030238 cites W1988581447 @default.
- W2102030238 cites W1990134753 @default.
- W2102030238 cites W2001763689 @default.
- W2102030238 cites W2006003888 @default.
- W2102030238 cites W2026659502 @default.
- W2102030238 cites W2032292168 @default.
- W2102030238 cites W2034410483 @default.
- W2102030238 cites W2045239910 @default.
- W2102030238 cites W2045400361 @default.
- W2102030238 cites W2045508612 @default.
- W2102030238 cites W2046473892 @default.
- W2102030238 cites W2046558738 @default.
- W2102030238 cites W2052990681 @default.
- W2102030238 cites W2058687283 @default.
- W2102030238 cites W2059351555 @default.
- W2102030238 cites W2094139874 @default.
- W2102030238 cites W2099478180 @default.
- W2102030238 cites W2102138781 @default.
- W2102030238 cites W2107754490 @default.
- W2102030238 cites W2112476814 @default.
- W2102030238 cites W2112891119 @default.
- W2102030238 cites W2122394503 @default.
- W2102030238 cites W2124784672 @default.
- W2102030238 cites W2131055855 @default.
- W2102030238 cites W2132056466 @default.
- W2102030238 cites W2134676768 @default.
- W2102030238 cites W2145564007 @default.
- W2102030238 cites W2147272268 @default.
- W2102030238 cites W2162010696 @default.
- W2102030238 cites W2164276105 @default.
- W2102030238 doi "https://doi.org/10.3174/ajnr.a4308" @default.
- W2102030238 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7964699" @default.
- W2102030238 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25907518" @default.
- W2102030238 hasPublicationYear "2015" @default.
- W2102030238 type Work @default.
- W2102030238 sameAs 2102030238 @default.
- W2102030238 citedByCount "41" @default.
- W2102030238 countsByYear W21020302382016 @default.
- W2102030238 countsByYear W21020302382017 @default.
- W2102030238 countsByYear W21020302382018 @default.
- W2102030238 countsByYear W21020302382019 @default.
- W2102030238 countsByYear W21020302382020 @default.
- W2102030238 countsByYear W21020302382021 @default.
- W2102030238 countsByYear W21020302382022 @default.
- W2102030238 countsByYear W21020302382023 @default.
- W2102030238 crossrefType "journal-article" @default.
- W2102030238 hasAuthorship W2102030238A5002716505 @default.
- W2102030238 hasAuthorship W2102030238A5009233581 @default.
- W2102030238 hasAuthorship W2102030238A5021628199 @default.
- W2102030238 hasAuthorship W2102030238A5024443914 @default.
- W2102030238 hasAuthorship W2102030238A5028785687 @default.
- W2102030238 hasAuthorship W2102030238A5045369725 @default.
- W2102030238 hasAuthorship W2102030238A5049470216 @default.
- W2102030238 hasAuthorship W2102030238A5063103450 @default.
- W2102030238 hasAuthorship W2102030238A5066130076 @default.
- W2102030238 hasAuthorship W2102030238A5070001088 @default.
- W2102030238 hasAuthorship W2102030238A5078434538 @default.
- W2102030238 hasAuthorship W2102030238A5082165277 @default.
- W2102030238 hasBestOaLocation W21020302381 @default.
- W2102030238 hasConcept C105702510 @default.
- W2102030238 hasConcept C126838900 @default.
- W2102030238 hasConcept C140530291 @default.
- W2102030238 hasConcept C15744967 @default.
- W2102030238 hasConcept C169760540 @default.
- W2102030238 hasConcept C2777348757 @default.
- W2102030238 hasConcept C2778186239 @default.
- W2102030238 hasConcept C2779246727 @default.
- W2102030238 hasConcept C2779534489 @default.
- W2102030238 hasConcept C2781099131 @default.
- W2102030238 hasConcept C54170458 @default.
- W2102030238 hasConcept C71924100 @default.
- W2102030238 hasConceptScore W2102030238C105702510 @default.
- W2102030238 hasConceptScore W2102030238C126838900 @default.
- W2102030238 hasConceptScore W2102030238C140530291 @default.
- W2102030238 hasConceptScore W2102030238C15744967 @default.