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- W2102034240 abstract "No AccessJournal of UrologyCLINICAL UROLOGY: Original Articles1 Jan 2004The Prediction of Renal Function 6 Years After Unilateral Nephrectomy Using Preoperative Risk Factors KEIICHI ITO, JUN NAKASHIMA, YASUMASA HANAWA, MOTOTSUGU OYA, TAKASHI OHIGASHI, KEN MARUMO, and MASARU MURAI KEIICHI ITOKEIICHI ITO More articles by this author , JUN NAKASHIMAJUN NAKASHIMA More articles by this author , YASUMASA HANAWAYASUMASA HANAWA More articles by this author , MOTOTSUGU OYAMOTOTSUGU OYA More articles by this author , TAKASHI OHIGASHITAKASHI OHIGASHI More articles by this author , KEN MARUMOKEN MARUMO More articles by this author , and MASARU MURAIMASARU MURAI More articles by this author View All Author Informationhttps://doi.org/10.1097/01.ju.0000100981.11470.2fAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Since middle-aged and elderly patients seem to have risk factors affecting renal function, it is important to predict postoperative renal function prior to unilateral nephrectomy (UNx). We evaluated preoperative factors for predicting postoperative renal function in middle-aged and elderly patients with renal cell carcinoma (RCC) treated with radical nephrectomy (RNx). Materials and Methods: In 201 patients who underwent RNx preoperative records and postoperative serum creatinine (SCR) 6 years after nephrectomy were available. Postoperative renal insufficiency was defined as serum creatinine 1.4 mg/dl or greater. The relationship of each preoperative and postoperative factor was analyzed. Logistic regression analysis was performed to evaluate preoperative factors for predicting postoperative SCR 1.4 mg/dl or greater after 6 years. Results: There was a significant difference in postoperative SCR between female and male patients, and between those with and without hypertension, diabetes and proteinuria (p <0.05). Age, hemoglobin, preoperative SCR, blood urea nitrogen, uric acid and K significantly correlated with postoperative SCR (p <0.05). The increase in SCR during 6 years after UNx was significantly higher in patients with hypertension, diabetes and proteinuria than in their respective counterparts (p <0.05). Multivariate stepwise logistic regression analysis demonstrated that preoperative serum creatinine, hypertension and proteinuria were significant independent factors predicting postoperative renal function 6 years after UNx in patients with RCC (p <0.05). Conclusions: Preoperative SCR, hypertension and proteinuria are useful factors for predicting postoperative renal function after RNx in patients with RCC. References 1 : Impact of renal donation. Long-term clinical and biochemical follow-up of living donors in a single center. Am J Med1985; 79: 201. Google Scholar 2 : Long-term blood pressure and renal function in kidney donors. Kidney Int1986; 29: 1072. Google Scholar 3 : Forty-five year follow-up after uninephrectomy. Kidney Int1993; 43: 1110. 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Google Scholar From the Department of Urology, School of Medicine, Keio University, Tokyo, Japan© 2004 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited bySun A, Thomas I, Velaer K, Ganesan C, Song S, Pao A, Wagner T, Brooks J, Chertow G and Leppert J (2020) The Urine Albumin-to-Creatinine Ratio and Kidney Function after NephrectomyJournal of Urology, VOL. 204, NO. 2, (231-238), Online publication date: 1-Aug-2020.Ohno Y, Nakashima J, Ohori M, Hashimoto T, Iseki R, Hatano T and Tachibana M (2011) Impact of Tumor Size on Renal Function and Prediction of Renal Insufficiency After Radical Nephrectomy in Patients With Renal Cell CarcinomaJournal of Urology, VOL. 186, NO. 4, (1242-1246), Online publication date: 1-Oct-2011.Gautam G, Lifshitz D, Shikanov S, Moore J, Eggener S, Shalhav A and Chang A (2010) Histopathological Predictors of Renal Function Decrease After Laparoscopic Radical NephrectomyJournal of Urology, VOL. 184, NO. 5, (1872-1876), Online publication date: 1-Nov-2010.Lucas S, Stern J, Adibi M, Zeltser I, Cadeddu J and Raj G (2007) Renal Function Outcomes in Patients Treated for Renal Masses Smaller Than 4 cm by Ablative and Extirpative TechniquesJournal of Urology, VOL. 179, NO. 1, (75-80), Online publication date: 1-Jan-2008.Sorbellini M, Kattan M, Snyder M, Hakimi A, Sarasohn D and Russo P (2018) Prognostic Nomogram for Renal Insufficiency After Radical or Partial NephrectomyJournal of Urology, VOL. 176, NO. 2, (472-476), Online publication date: 1-Aug-2006. Volume 171Issue 1January 2004Page: 120-125 Advertisement Copyright & Permissions© 2004 by American Urological Association, Inc.Keywordsnephrectomycarcinoma, renal cellcreatininekidneyMetricsAuthor Information KEIICHI ITO More articles by this author JUN NAKASHIMA More articles by this author YASUMASA HANAWA More articles by this author MOTOTSUGU OYA More articles by this author TAKASHI OHIGASHI More articles by this author KEN MARUMO More articles by this author MASARU MURAI More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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